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Phospho-Doublecortin (Ser335) Antibody (PA5-102854) in IHC (P)
Immunohistochemistry analysis of Phospho-Doublecortin (Ser335) in rat brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-Doublecortin (Ser335) polyclonal antibody (Product # PA5-102854) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102854
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DCX(Accession O43602), corresponding to amino acid residues around phosphorylated Ser335.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815939
产品详细信息
Antibody detects endogenous levels of Doublecortin only when phosphorylated at Ser335.
靶标信息
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: doublecortex; Doublin; Lis-X; LIS-XD; Lissencephalin-X; lissencephaly, X-linked (doublecortin); Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316
基因别名: DBCN; Dbct; DC; Dcn; DCX; LISX; SCLH; XLIS
UniProt ID: (Human) O43602, (Mouse) O88809
Entrez Gene ID: (Human) 1641, (Rat) 84394, (Mouse) 13193
neuron migration
brain development
central nervous system projection neuron axonogenesis
intracellular signal transduction
axon extension
dendrite morphogenesis
response to electrical stimulus
multicellular organism development
nervous system development
peptidyl-serine phosphorylation
cell differentiation
protein autophosphorylation
central nervous system development
hippocampus development
layer formation in cerebral cortex
pyramidal neuron development
