Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
BS-5335R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic phosphopeptide derived from human ELk1 around the phosphorylation site of Ser389 [PR (p-S)PA].
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: ELK 1; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene
基因别名: Elk-1; ELK1
UniProt ID: (Human) P19419, (Mouse) P41969, (Rat) A4GTP4
Entrez Gene ID: (Human) 2002, (Mouse) 13712, (Rat) 314436
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
double-stranded DNA binding
sequence-specific DNA binding
winged helix/forkhead transcription factor
transcription from RNA polymerase II promoter
response to light stimulus
cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to testosterone stimulus
cellular response to gamma radiation
response to fibroblast growth factor
positive regulation of neuron death
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cellular response to lipid
