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Antibody detects endogenous levels of EPHB1/2/3/4 only when phosphorylated at Tyr600/602/614/596.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Developmental kinase 2; Developmental kinase 5; Developmentally-regulated Eph-related tyrosine kinase; EK2; EK5; EK6; ELK; ELK-related protein tyrosine kinase; ELK-related tyrosine kinase; Embryonic kinase 2; Eph receptor B2 (ELK-related protein tyrosine kinase); EPH receptor B4; EPH tyrosine kinase 2; EPH tyrosine kinase 3; EPH-like kinase 2; EPH-like kinase 5; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; ephrin receptor EphB4; Ephrin type-B receptor 1; Ephrin type-B receptor 2; Ephrin type-B receptor 3; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; human embryo kinase 2; mDK-2; mDK-5; NET; Neural kinase; Neuronally-expressed EPH-related tyrosine kinase; Nuk receptor tyrosine kinase; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; soluble EPHB1 variant 1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyrosine kinase MYK-1; Tyrosine-protein kinase receptor EPH-2; Tyrosine-protein kinase receptor EPH-3; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase receptor SEK-3; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO11; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase TYRO6
基因别名: 9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; CAPB; Cek10; Cek5; Cek6; DRT; EK2; EK5; ELK; Elkh; ENSMUSG00000074119; EPHB1; EPHB2; EPHB3; EPHB4; EPHT2; EPHT3; Epth2; EPTH3; ERK; ETECK; ETK2; HEK2; HEK5; HEK6; HTK; MDK2; MDK5; MYK1; NET; Nuk; PCBC; Prkm5; Qek5; RGD1564232; Sek3; Sek4; TYRO11; TYRO5; TYRO6
UniProt ID: (Human) P54762, (Human) P29323, (Human) P54753, (Human) P54760, (Rat) P09759, (Mouse) Q8CBF3, (Mouse) P54763, (Mouse) P54754, (Mouse) P54761
Entrez Gene ID: (Human) 2047, (Human) 2048, (Human) 2049, (Human) 2050, (Rat) 24338, (Mouse) 270190, (Mouse) 13844, (Rat) 313633, (Mouse) 13845, (Rat) 287989, (Rat) 686310, (Mouse) 13846
分子生物学功能:
transmembrane signal receptor