Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
Phospho-FANCD2 (Ser717) Antibody (PA5-106174) in WB
Western blot analysis of Phospho-FANCD2 (Ser717) in mouse brain tissue lysate (absence (-) or presence (+) of non-phospho and phospho peptide). Samples were incubated with Phospho-FANCD2 (Ser717) polyclonal antibody (Product # PA5-106174).
产品信息
PA5-106174
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FANCD2(Accession Q9BXW9), corresponding to amino acid residues around phosphorylated Ser717.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817572
产品详细信息
Antibody detects endogenous levels of FANCD2 only when phosphorylated at Ser717.
靶标信息
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: DKFZp762A223; FACD2; Fanconi anemia group D2 protein; Fanconi anemia group D2 protein homolog; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2
基因别名: 2410150O07Rik; AU015151; BB137857; FA-D2; FA4; FACD; FAD; FAD2; FANCD; FANCD2
UniProt ID: (Human) Q9BXW9, (Mouse) Q80V62
Entrez Gene ID: (Human) 2177, (Mouse) 211651
