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Phospho-GluR2 (Ser880) Antibody (PA5-104897) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-GluR2 (Ser880) in human brain tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-GluR2 (Ser880) polyclonal antibody (Product # PA5-104897) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-104897
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GRIA2(Accession P42262), corresponding to amino acid residues around phosphorylated Ser880.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816370
产品详细信息
Antibody detects endogenous levels of GluR2 only when phosphorylated at Serine 880.
靶标信息
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5 -methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; glutamate receptor; Glutamate receptor 2; glutamate receptor B; glutamate receptor B flip isoform; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943
基因别名: GluA2; Glur-2; GluR-B; GluR-K2; GLUR2; GLURB; GRIA2; HBGR2
UniProt ID: (Human) P42262, (Rat) P19491
Entrez Gene ID: (Human) 2891, (Mouse) 14800, (Rat) 29627
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
excitatory extracellular ligand-gated ion channel activity
extracellular-glutamate-gated ion channel activity
protein binding
receptor activity
ion channel activity
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
calcium channel regulator activity
transmembrane signal receptor
signal transduction
chemical synaptic transmission
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
regulation of receptor recycling
transport
ion transport
receptor internalization
synaptic transmission, glutamatergic
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to lithium ion
response to fungicide
