Invitrogen

Phospho-Histone H2A (Ser139) Monoclonal Antibody (GT1021)

Phospho-Histone H2A (Ser139) Antibody in Immunocytochemistry (ICC/IF)

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Phospho-Histone H2A (Ser139) Antibody (MA5-31471) in ICC/IF

Phospho-Histone H2A (Ser139) Monoclonal Antibody (GT1021) detects Histone H2A. XS139ph (phospho Ser139) protein at Nucleus by immunofluorescent analysis. Sample: 10 µM Cisplatin for 24 hrs HeLa cells were fixed in 4% paraformaldehyde/PBS for 15 min. Green: Histone H2A. XS139ph (phospho Ser139) protein stained by Phospho-Histone H2A (Ser139) Monoclonal Antibody (GT1021) (Product # MA5-31471) diluted at 1:500... View More

Phospho-Histone H2A (Ser139) Antibody in Western Blot (WB)

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产品信息

MA5-31471

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫细胞化学 (ICC/IF)

1:100-1:1,000

产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

GT1021

抗原

Carrier-protein conjugated synthetic peptide corresponding to residues around human Histone H2A.XS139ph (phospho Ser139).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.05 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2787103

产品详细信息

Keep as concentrated solution.

Positive Control: HCT116 (30 µM Cisplatin treatment for 24hr).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner.

Cell death and differentiation

Ragu S,Droin N,Matos-Rodrigues G,Barascu A,Caillat S,Zarkovic G,Siberchicot C,Dardillac E,Gelot C,Guirouilh-Barbat J,Radicella JP,Ishchenko AA,Ravanat JL,Solary E,Lopez BS

MA5-31471 was used in Western Blotting to characterize a noncanonical cellular response that is specific to nonblocking replication stress.

Mon May 01 00:00:00 EDT 2023

生物信息学

蛋白别名: Acetyl-Histone H2; H2A 615 antibody; H2A GL101 antibody; H2A histone family member; H2A histone family, member A; H2A histone family, member C; H2A histone family, member E; H2A histone family, member G; H2A histone family, member M; H2A histone family, member P; H2A histone family, member R; H2A histone family, member X; H2A histone family, member Z; H2A-clustered histone 1; H2A-clustered histone 12; H2A-clustered histone 6; H2A.1; H2A.1 antibody; H2A/d; H2a/x; H2A/z; h2ad; H2ae; h2ai; H2ak; H2AK5ac; H2AX histone; H2AZ histone; H2B histone family, member U, (testis-specific); HIS; HIST1H2AE antibody; HIST3H2A; histone 1, H2aa; histone 1, H2ab; histone 1, H2ad; histone 1, H2ae; histone 1, H2ag; histone 1, H2ah; histone 1, H2ai; histone 1, H2aj; histone 1, H2ba; histone 2, H2ai; histone 5 protein 2ax; Histone H2A type 1; Histone H2A type 1-A; Histone H2A type 1-B; Histone H2A type 1-B/E; Histone H2A type 1-C; Histone H2A type 1-D; Histone H2A type 1-E; Histone H2A type 1-G; Histone H2A type 1-H; Histone H2A type 1-I; Histone H2A type 1-J; Histone H2A type 1-N; Histone H2A type 1-O; Histone H2A type 1-P; Histone H2A.2; Histone H2A.3; Histone H2A.X; Histone H2A.Z; Histone H2A/a; Histone H2A/e; Histone H2A/g; Histone H2A/m; histone H2A/p; Histone H2A/ptl; Histone H2A/r; Histone H2A/s; histone H2AD; histone H2AE; Histone H2AX; Histone H2B type 1-A; Histone H2B, testis; MGC74460 antibody; Testis-specific histone H2B; TSH2B.1

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基因别名: 1190022L06; AW228881; bA317E16.2; bA317E16.3; dJ160A22.4; dJ86C11.1; gammaH2ax; H2a-291A; H2a-53; H2A.1; H2A.1b; H2A.2; H2A.3; H2A.X; H2A.Z; H2A.Z-1; H2A/a; H2A/c; H2A/E; H2A/g; H2A/m; H2A/p; H2A/S; H2A/X; H2A/z; H2AA; H2AC1; H2AC11; H2AC12; H2AC13; H2AC14; H2AC15; H2AC16; H2AC17; H2AC4; H2ac6; H2AC7; H2AC8; H2AFA; H2AFALii; H2AFC; H2AFD; H2AFE; H2AFG; H2AFI; H2AFM; H2AFN; H2AFP; H2AFR; H2AFX; H2AFZ; H2AG; H2AH; H2AX; H2AZ; H2AZ1; H2BC1; H2BFU; HIST1H2AA; HIST1H2AB; Hist1h2ac; HIST1H2AD; HIST1H2AE; HIST1H2AG; HIST1H2AH; HIST1H2AI; HIST1H2AJ; HIST1H2AK; HIST1H2AL; HIST1H2AM; Hist1h2an; Hist1h2ao; Hist1h2ap; HIST1H2BA; Hist5-2ax; pH2A/f; STBP; TH2A; TH2B; TSH2B; TSH2B.1