AbboMax

Phospho-IRAK4 (Thr345) Monoclonal Antibody (A8A8)

Phospho-IRAK4 (Thr345) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-IRAK4 (Thr345) Antibody (600-560) in IHC (P)

Immunohistochemistry: Human lung squamous carcinoma (FFPE) stained with Mouse anti- IRAK4(pT345) (Cat# 600-560) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Phospho-IRAK4 (Thr345) Antibody in Western Blot (WB)

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产品信息

600-560

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-1 µg/mL

免疫组化（石蜡） (IHC (P))

2-10 µg/mL

产品规格

种属反应

Bovine, Dog, Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

A8A8

抗原

A synthetic peptide surrounding to the epitope -VMTSR- with a phosphorylation site at Thr345 of human IRAK-4 protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

25mM tris with proprietary stabilizer

内含物

0.01% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Positive control: Jurkat Cell lysate

Cellular location: Cytoplasmic.

靶标信息

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。