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Phospho-JAK1 (Tyr1034, Tyr1035) Polyclonal Antibody, Biotin

查看其他22个JAK1抗体

产品信息

PJAK1-BIOTIN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化 (IHC)

1:50-1:250

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 1000-1050 on human JAK1 protein. Phosphorylated 1034 & 1035 tyrosine residues.

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偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: EC 2.7.10.2; JAK-1; Janus kinase 1; Janus protein tyrosine kinase 1; kinase Jak1; Tyrosine-protein kinase JAK1

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基因别名: AA960307; BAP004; C130039L05Rik; JAK1; JAK1A; JAK1B; JTK3

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UniProt ID: (Human) P23458

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Entrez Gene ID: (Human) 3716, (Rat) 84598, (Mouse) 16451

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protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity receptor binding growth hormone receptor binding protein binding ATP binding protein phosphatase binding ubiquitin protein ligase binding CCR5 chemokine receptor binding metal ion binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

参与通路

enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway cell migration peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cell differentiation intracellular signal transduction peptidyl-tyrosine autophosphorylation interleukin-2-mediated signaling pathway regulation of cell proliferation innate immune response response to antibiotic protein autophosphorylation MAPK cascade protein phosphorylation positive regulation of GTPase activity interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway positive regulation of sprouting angiogenesis phosphorylation