Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PJAK3-BIOTIN
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 750-800 on human JAK3 protein. Phosphorylated tyrosine 785 residue.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Breast-JAK3; JAK-3; JAK3B; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; L JAK; L-JAK; Leukocyte janus kinase; Tyrosine-protein kinase JAK3
基因别名: fae; JAK-3; JAK3; JAK3_HUMAN; JAKL; L-JAK; LJAK; RATJAK3; wil
UniProt ID: (Human) P52333, (Mouse) Q62137, (Rat) Q63272
Entrez Gene ID: (Human) 3718, (Mouse) 16453, (Rat) 25326
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
protein binding
ATP binding
protein phosphatase binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
hormone receptor binding
transcription factor binding
MAPK cascade
adaptive immune response
negative regulation of dendritic cell cytokine production
protein phosphorylation
enzyme linked receptor protein signaling pathway
positive regulation of cytosolic calcium ion concentration
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
cell migration
peptidyl-tyrosine phosphorylation
B cell differentiation
negative regulation of interleukin-10 production
negative regulation of interleukin-12 production
intracellular signal transduction
interleukin-4-mediated signaling pathway
peptidyl-tyrosine autophosphorylation
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
tyrosine phosphorylation of Stat5 protein
T cell homeostasis
positive regulation of GTPase activity
innate immune response
negative regulation of FasL biosynthetic process
negative regulation of T-helper 1 cell differentiation
positive regulation of immune response
negative regulation of T cell activation
positive regulation of calcium ion transport
JAK-STAT cascade involved in growth hormone signaling pathway
regulation of T cell apoptotic process
negative regulation of thymocyte apoptotic process
response to interleukin-2
response to interleukin-4
response to interleukin-15
response to interleukin-9
immune system process
transmembrane receptor protein tyrosine kinase signaling pathway
phosphorylation
cytokine-mediated signaling pathway
erythrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
lymph node development
positive regulation of dendritic cell apoptotic process
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
inflammatory response
regulation of apoptotic process
