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Invitrogen
Phospho-JNK1 (Thr183) Polyclonal Antibody
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
图: 1 / 3
Phospho-JNK1 (Thr183) Antibody (PA5-37698) in IHC (P)
Immunohistochemical analysis of Phospho-JNK1 (Thr183) in paraffin-embedded Human breast carcinoma tissue using Phospho-JNK1 (Thr183) Polyclonal Antibody (Product # PA5-37698) (left) or the same antibody preincubated with blocking peptide (right).
产品信息
PA5-37698
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide sequence around phosphorylation site of threonine 183 (M-M-T(p)-P-Y) derived from Human SAPK/JNK.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2554306
产品详细信息
A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human breast carcinoma.
靶标信息
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: c-Jun N-terminal kinase 1; FLJ12099; FLJ33785; JNK-46; JNK1 beta1 protein kinase; JNK3; JNK3A; JUN N-terminal kinase; MAP kinase 8; MAPK 10; MAPK 8; MAPK10; MGC50974; mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; MK10; OTTHUMP00000019552; p493F12; p54 gamma; p54bSAPK; Phospho-JNK; PRKM10; protein kinase JNK1; protein kinase mitogen-activated 8; SAPK gamma; SAPK1c; stress-activated protein kinase 1; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1
基因别名: AI849689; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; MAPK8; PRKM8; SAPK1; SAPK1C
UniProt ID: (Human) P45983, (Rat) P49185, (Mouse) Q91Y86
Entrez Gene ID: (Human) 5599, (Rat) 116554, (Mouse) 26419
protein serine/threonine kinase activity
JUN kinase activity
protein binding
ATP binding
kinase activity
enzyme binding
histone deacetylase regulator activity
histone deacetylase binding
nucleotide binding
protein kinase activity
MAP kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
response to stress
JNK cascade
JUN phosphorylation
response to UV
positive regulation of gene expression
regulation of macroautophagy
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
regulation of histone deacetylation
positive regulation of cyclase activity
negative regulation of protein binding
regulation of protein localization
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of apoptotic process
rhythmic process
regulation of sequence-specific DNA binding transcription factor activity
positive regulation of protein metabolic process
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
positive regulation of deacetylase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
ossification
regulation of transcription, DNA-templated
inflammatory response
response to osmotic stress
signal transduction
response to heat
regulation of gene expression
phosphorylation
positive regulation of cell migration
positive regulation of microtubule polymerization
neuron projection development
response to hydrogen peroxide
positive regulation of DNA replication
response to cadmium ion
determination of dorsal identity
cellular response to hydrogen peroxide
cellular response to nitric oxide
type B pancreatic cell apoptotic process
neuronal stem cell population maintenance
programmed necrotic cell death
positive regulation of determination of dorsal identity
positive regulation of apoptotic signaling pathway
