Invitrogen

Phospho-Jak1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (Jak1Y10221023-F11), FITC

Phospho-Jak1 (Tyr1022, Tyr1023) Antibody in Flow Cytometry (Flow)

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Phospho-Jak1 (Tyr1022, Tyr1023) Antibody (MA5-36892) in Flow

Flow cytometry of Phospho-Jak1 (Tyr1022, Tyr1023) using Jurkat cells. Samples were incubated in monoclonal Phospho-Jak1 (Tyr1022, Tyr1023) antibody (Product # MA5-36892). Images correspond with the following conditions: untreated, unstained negative control (blue), untreated (red), treated with IFNa/IL-4/pervanadate (green).

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产品信息

MA5-36892

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

5 µL/1x10^6 cells

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

Jak1Y10221023-F11

抗原

A synthetic phospho-peptide corresponding to residues surrounding Tyr1022/1023 of human phospho-Jak1.

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偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

纯化类型

Protein A/G

保存液

PBS with 0.20% BSA

内含物

0.09% sodium azide

保存条件

4° C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2896827

靶标信息

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

仅用于科研。不用于诊断过程。未经明确授权不得转售。