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Antibody detects endogenous levels of MAX only when phosphorylated at Ser11.
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bHLHd4; Class D basic helix-loop-helix protein 4; Delta-Max; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; Myc-associated factor X; Myc-binding novel HLH/LZ protein; orf1; Protein max; Protein myn
基因别名: AA960152; AI875693; BHLHD4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; MAX; Myn
UniProt ID: (Human) P61244, (Mouse) P28574, (Rat) P52164
Entrez Gene ID: (Human) 4149, (Mouse) 17187, (Rat) 60661