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This antibody is predicted to react with mouse and rat based on sequence homology.
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bruton agammaglobulinemia tyrosine kinase; c-mer proto-oncogene tyrosine kinase; EC 2.7.10.2; Etk2/tyro3; kinase Syk; KSYK; MER receptor tyrosine kinase; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; SYK; TK19-2; Tyro 12; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase Mer; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF
基因别名: AI323366; Brt; BYK; c-Eyk; c-mer; DTK; Etk-2; etk2/tyro3; Eyk; MER; MERTK; nmf12; Nyk; rdy; Rek; RP38; RSE; SKY; TIF; TK19-2; Tyro12; TYRO3
UniProt ID: (Human) Q12866, (Mouse) Q60805, (Rat) P57097, (Human) Q06418, (Mouse) P55144, (Rat) P55146
Entrez Gene ID: (Human) 10461, (Mouse) 17289, (Rat) 65037, (Human) 7301, (Mouse) 22174, (Rat) 25232