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Invitrogen
Phospho-MKK7 (Ser271, Thr275) Recombinant Rabbit Monoclonal Antibody (MKK7S271T275-R4F9)
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Phospho-MKK7 (Ser271, Thr275) Antibody (MA5-37005) in WB
Western blot analysis of Phospho-MKK7 (Ser271, Thr275) using THP1 cell extract. Samples were untreated or treated with sorbitol, and incubated in monoclonal Phospho-MKK7 (Ser271, Thr275) antibody (Product # MA5-37005) with a dilution of 0.1 µg/mL.
产品信息
MA5-37005
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MKK7S271T275-R4F9
抗原
A synthetic phospho-peptide corresponding to residues surrounding Ser271/Thr275 of human phospho MKK7.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2896940
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; MAP kinase kinase 7; MAP2K4; map2k7; map2k7 {ECO:0000312|EMBL:AAX61178.1}; MAPK/ERK kinase 7; MAPKK 4; MAPKK 7; MEK 7; mitogen activated protein kinase kinase 7; protein kinase, mitogen activated, kinase 7; SAPK kinase 4; SAPKK-1; SAPKK1; Stress-activated protein kinase kinase 4
基因别名: JNKK; 2; 5930412N11Rik; JNKK 2; JNKK2; MAP2K7; MAPKK 7; MAPKK7; MEK; MEK 7; MEK7; MKK7; PRKMK7; SAPKK-4; SAPKK4; sek2; SKK4
UniProt ID: (Human) O14733, (Rat) Q4KSH7, (Mouse) Q8CE90
Entrez Gene ID: (Human) 5609, (Rat) 363855, (Mouse) 26400
magnesium ion binding
receptor signaling protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
protein C-terminus binding
JUN kinase kinase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
protein serine/threonine kinase activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
apoptotic process
response to osmotic stress
signal transduction
JNK cascade
activation of JUN kinase activity
response to heat
response to UV
peptidyl-tyrosine phosphorylation
positive regulation of telomere maintenance via telomerase
response to tumor necrosis factor
proteolysis in other organism
Fc-epsilon receptor signaling pathway
positive regulation of neuron apoptotic process
stress-activated MAPK cascade
positive regulation of telomerase activity
cellular response to sorbitol
positive regulation of telomere capping
positive regulation of protein phosphorylation
protein phosphorylation
MAPK cascade
response to stress
phosphorylation
