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Phospho-MPZL1 (Tyr263) Antibody (PA5-114629) in IHC (P)
Immunohistochemistry analysis of Phospho-MPZL1 (Tyr263) in mouse lung tissue sections. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114629) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
产品信息
PA5-114629
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MPZL1(Accession O95297), corresponding to amino acid residues around phosphorylated Tyr263.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2899265
产品详细信息
Antibody detects endogenous levels of PZR only when phosphorylated at Tyr263.
靶标信息
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ21047; immunoglobulin family transmembrane protein; myelin protein zero-like 1; Myelin protein zero-like protein 1; protein zero related; Protein zero-related
基因别名: 1110007A10Rik; MPZL1; MPZL1b; PZR; PZR1b; PZRa; PZRb; UNQ849/PRO1787
UniProt ID: (Human) O95297, (Rat) Q6AYT8, (Mouse) Q3TEW6
Entrez Gene ID: (Human) 9019, (Rat) 360871, (Mouse) 68481
