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Phospho-NACA (Thr159) Antibody (PA5-118705) in IHC (P)
Immunohistochemical analysis of Phospho-NACA (Thr159) in Mouse testis tissue using a Phospho-NACA (Thr159) polyclonal antibody (Product # PA5-118705). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondar... View More
产品信息
PA5-118705
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NACA(Accession Q13765), corresponding to amino acid residues around phosphorylated Thr159.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903205
产品详细信息
Antibody detects endogenous levels of NACA only when phosphorylated at Thr159.
靶标信息
NACA prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites), and may act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-NAC; Alpha-NAC, muscle-specific form; Alpha-NAC/1.9.2; NAC-alpha; nascent polypeptide-associated complex alpha subunit; Nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; nascent-polypeptide-associated complex alpha polypeptide; skNAC
基因别名: AL022831; AL024382; Gm1878; HSD48; mKIAA0363; NAC-alpha; NACA; NACA1; skNAC
UniProt ID: (Human) Q13765, (Mouse) Q60817
Entrez Gene ID: (Human) 4666, (Rat) 288770, (Mouse) 17938
transcription, DNA-templated
regulation of transcription, DNA-templated
cardiac ventricle development
negative regulation of striated muscle cell apoptotic process
skeletal muscle tissue regeneration
positive regulation of skeletal muscle tissue growth
regulation of skeletal muscle fiber development
myoblast migration
heart trabecula morphogenesis
negative regulation of transcription from RNA polymerase II promoter involved in heart development
positive regulation of transcription from RNA polymerase II promoter involved in heart development
regulation of nucleic acid-templated transcription
positive regulation of cell proliferation involved in heart morphogenesis
transport
protein transport
