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Phospho-OPRM1 (Ser377) Antibody (PA5-105163) in WB
Western blot analysis of Phospho-OPRM1 (Ser375) in mouse brain (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-OPRM1 (Ser375) polyclonal antibody (Product # PA5-105163).
产品信息
PA5-105163
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human OPRM1(Accession P35372), corresponding to amino acid residues around phosphorylated Ser377.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816636
产品详细信息
Antibody detects endogenous levels of OPRM1 only when phosphorylated at Ser377, which site historically referenced as Ser375.
靶标信息
The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hMOP; KIAA0403; M-OR-1; MOP; MOP receptor; MOR-1C; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant mMOR-1Z; Mu-type opioid receptor; Opioid mu receptor; Opioid Receptor; opioid receptor, mu 1; OTTHUMP00000017463
基因别名: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; muOR; OPRM; OPRM1
UniProt ID: (Human) P35372, (Mouse) P42866
Entrez Gene ID: (Human) 4988, (Mouse) 18390
G-protein alpha-subunit binding
G-protein coupled receptor activity
beta-endorphin receptor activity
voltage-gated calcium channel activity
protein binding
protein C-terminus binding
protein domain specific binding
filamin binding
G-protein beta-subunit binding
morphine receptor activity
neuropeptide binding
signal transducer activity
opioid receptor activity
G-protein coupled receptor
transmembrane signal receptor
acute inflammatory response to antigenic stimulus
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating dopamine receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
sensory perception
locomotory behavior
negative regulation of cell proliferation
response to radiation
sensory perception of pain
adenylate cyclase-inhibiting opioid receptor signaling pathway
response to food
positive regulation of appetite
response to lipopolysaccharide
cellular response to stress
wound healing
response to cocaine
eating behavior
estrous cycle
behavioral response to ethanol
positive regulation of neurogenesis
regulation of sensory perception of pain
excitatory postsynaptic potential
negative regulation of Wnt protein secretion
positive regulation of ERK1 and ERK2 cascade
calcium ion transmembrane transport
response to growth factor
cellular response to morphine
regulation of N-methyl-D-aspartate selective glutamate receptor activity
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of cAMP biosynthetic process
opioid receptor signaling pathway
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
negative regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
negative regulation of cytosolic calcium ion concentration
