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Phospho-PER2 (Ser662) Antibody (PA5-105052) in IHC (P)
Immunohistochemistry analysis of Phospho-PER2 (Ser662) in mouse ovarian tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-PER2 (Ser662) polyclonal antibody (Product # PA5-105052) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-105052
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PER2(Accession O15055), corresponding to amino acid residues around phosphorylated Ser662.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816525
产品详细信息
Antibody detects endogenous levels of PER2 only when phosphorylated at Ser662.
靶标信息
PER2, also known as Period circadian protein homolog 2, is a mainly nuclear protein that shows nucleocytoplasmic shuttling which is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. PER2 belongs to the basic helix-loop-helix family of transcription factors and contains a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. PER2 is a component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. This protein is thus essential for generating circadian rhythms and is a negative element in the circadian transcriptional loop which influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Expression of PER2 is fairly wide spread with strong expression in skeletal muscle and pancreas and slight expression in lung. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Circadian clock protein PERIOD 2; hPER2; mPER2; per2 {ECO:0000312|RGD:61945}; period 2; period circadian protein 2; Period circadian protein homolog 2; period homolog 2; rPER2
基因别名: FASPS; FASPS1; KIAA0347; mKIAA0347; mPer2; PER2; rPER2
UniProt ID: (Human) O15055, (Mouse) O54943, (Rat) Q9Z301
Entrez Gene ID: (Human) 8864, (Mouse) 18627, (Rat) 63840
transcription regulatory region sequence-specific DNA binding
transcription factor activity, transcription factor binding
transcription coactivator activity
protein binding
ubiquitin binding
core promoter binding
transcription corepressor binding
signal transducer activity
kinase binding
nuclear hormone receptor binding
pre-mRNA binding
histone deacetylase binding
RNA polymerase binding
histone methyltransferase binding
transcription cofactor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
response to ischemia
glycogen biosynthetic process
gluconeogenesis
transcription, DNA-templated
fatty acid metabolic process
circadian rhythm
regulation of vasoconstriction
lactate biosynthetic process
negative regulation of protein ubiquitination
circadian regulation of gene expression
regulation of circadian rhythm
negative regulation of circadian rhythm
negative regulation of transcription, DNA-templated
regulation of neurogenesis
regulation of insulin secretion
white fat cell differentiation
regulation of cell cycle
regulation of glutamate uptake involved in transmission of nerve impulse
negative regulation of fat cell proliferation
histone H3 deacetylation
circadian regulation of translation
negative regulation of transcription regulatory region DNA binding
signal transduction
negative regulation of DNA-templated transcription, termination
