Product References
Epigenetic upregulation of MNAT1 by SMYD2 is linked to PI3K/AKT activation and tumorigenesis of pancreatic adenocarcinoma.
Histology and histopathology
Xu Z,Liu Y,Pan Z,Qin L
PA5-104853 was used in Western Blot to investigate the roles of SMYD2 and its interacted molecules in pancreatic adenocarcinoma (PAAD).
Thu Feb 01 00:00:00 EST 2024
Tumor Cell-Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β-Oxidation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li J,Xia Q,Di C,Li C,Si H,Zhou B,Yu S,Li Y,Huang J,Lu Y,Huang M,Liang H,Liu X,Zhao Q
PA5-104853 was used in Western Blot to show that CD96 is frequently expressed in tumor cells from clinical breast cancer samples and is correlated with poor long-term prognosis in these patients.
Wed Mar 01 00:00:00 EST 2023
Salvigenin Suppresses Hepatocellular Carcinoma Glycolysis and Chemoresistance Through Inactivating the PI3K/AKT/GSK-3β Pathway.
Applied biochemistry and biotechnology
Shao H,Chen J,Li A,Ma L,Tang Y,Chen H,Chen Y,Liu J
PA5-104853 was used in Western Blotting to investigate the inhibitory effects of Salvigenin on hepatocellular carcinoma (HCC) cells, particularly focusing on its impact on HCC cell proliferation, migration, invasion, glycolysis, 5-fluorouracil (5-FU) sensitivity, and the underlying mechanism involving the PI3K/AKT/GSK-3β pathway.
Tue Aug 01 00:00:00 EDT 2023
PTPN22 activates the PI3K pathway via 14-3-3τ in T cells.
The FEBS journal
Bai B,Wang T,Zhang X,Ba X,Zhang N,Zhao Y,Wang X,Yu Y,Wang B
PA5-104853 was used in Immunocytochemistry to determine that PTPN22 binds to 14-3-3τ via the PTPN22-Ser640 phosphorylation side.
Fri Sep 01 00:00:00 EDT 2023
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Cancers
Jiang Q,Lei Z,Wang Z,Wang Q,Zhang Z,Liu X,Xing B,Li S,Guo X,Liu Y,Li X,Qi Y,Shu K,Zhang H,Huang Y,Lei T
PA5-104853 was used in Western Blotting to demonstrate that ONECUT2 transcriptionally increased fibroblast growth factor receptor 3 (FGFR3) expression, which further activates the mitogen-activated protein kinases (MAPK) pathway, thus promoting PA progression.
Tue Jun 27 00:00:00 EDT 2023
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Cancers
Jiang Q,Lei Z,Wang Z,Wang Q,Zhang Z,Liu X,Xing B,Li S,Guo X,Liu Y,Li X,Qi Y,Shu K,Zhang H,Huang Y,Lei T
PA5-104853 was used in Western Blotting to demonstrate that ONECUT2 transcriptionally increased fibroblast growth factor receptor 3 (FGFR3) expression, which further activates the mitogen-activated protein kinases (MAPK) pathway, thus promoting PA progression.
Tue Jun 27 00:00:00 EDT 2023
Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.
Antioxidants & redox signaling
Potor L,Hendrik Z,Patsalos A,Katona É,Méhes G,Póliska S,Csősz É,Kalló G,Komáromi I,Combi Z,Posta N,Sikura KÉ,Pethő D,Oros M,Vereb G,Tóth C,Gergely P,Nagy L,Balla G,Balla J
PA5-104853 was used in Western Blot to conclude that ferrylHb in atherosclerotic lesion provokes the progression of the disease via polarizing macrophages.
Wed Oct 20 00:00:00 EDT 2021
Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes.
Journal of personalized medicine
Lachén-Montes M,Íñigo-Marco I,Cartas-Cejudo P,Fernández-Irigoyen J,Santamaría E
PA5-104853 was used in Western Blot to assess olfactory bulb (OB) proteome-wide expression in mixed dementia subjects (n = 6) respect to neurologically intact controls (n = 7).
Thu Jun 03 00:00:00 EDT 2021
Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K/AKT/FOXO3 pathway.
Annals of translational medicine
Liu H,Chen W,Lu P,Ma Y,Liang X,Liu Y
PA5-104853 was used in Western Blotting to suggest that Rg1 may be a potential therapeutic agent for DN treatment.
Wed Dec 01 00:00:00 EST 2021
Kaempferol Inhibits Zearalenone-Induced Oxidative Stress and Apoptosis via the PI3K/Akt-Mediated Nrf2 Signaling Pathway: In Vitro and In Vivo Studies.
International journal of molecular sciences
Rajendran P,Ammar RB,Al-Saeedi FJ,Mohamed ME,ElNaggar MA,Al-Ramadan SY,Bekhet GM,Soliman AM
Published figure using Phospho-PI3K p85 alpha (Tyr607) polyclonal antibody (Product # PA5-104853) in Western Blot
Mon Dec 28 00:00:00 EST 2020