Invitrogen

Phospho-PKC theta (Ser695) Polyclonal Antibody

Phospho-PKC theta (Ser695) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-PKC theta (Ser695) Antibody (PA5-37697) in IHC (P)

Immunohistochemical analysis of Phospho-PKC theta (Ser695) in paraffin-embedded Human lung carcinoma tissue using Phospho-PKC theta (Ser695) Polyclonal Antibody (Product # PA5-37697) (left) or the same antibody preincubated with blocking peptide (right).

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产品信息

PA5-37697

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500

免疫组化（石蜡） (IHC (P))

1:50-1:100

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide sequence around phosphorylation site of serine 695 (N-F-S(p)-F-M) derived from Human PKC-theta

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2554305

产品详细信息

A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human lung carcinoma.

靶标信息

Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that govern a wide range of physiological processes including differentiation, proliferation, gene expression, brain function, membrane transport and the organization of cytoskeletal and extracellular matrix proteins. Increasing evidence from studies using in vitro and in vivo systems points to PKC as a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the G1 and G2 checkpoints. PKC-mediated control of these transitions can be negative or positive, depending on the timing of PKC activation during the cell cycle and on the specific PKC isozymes involve. There have been at least 12 different PKC isoforms identified in humans to date, including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. The different PKC isoforms vary in structure, subcellular localization, tissue distribution and response to extracellular signals. PKC beta II has been shown to be expressed, in part, in cardiac muscle, intestinal epithelium, kidney and pancreas. PKC beta II has been shown to be involved in cell cycle progression and cancer proliferation.

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