Invitrogen

Phospho-PLK1 (Thr210) Recombinant Rabbit Monoclonal Antibody (PLK1T210-C2), APC

Phospho-PLK1 (Thr210) Antibody in Flow Cytometry (Flow)

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Phospho-PLK1 (Thr210) Antibody (MA5-37127) in Flow

Flow cytometry of Phospho-PLK1 (Thr210) using HeLa cells. Samples were incubated in monoclonal Phospho-PLK1 (Thr210) antibody (Product # MA5-37127). Images correspond with the following conditions: untreated, unstained negative control (blue), untreated and stained (red), treated with nocodazole and stained (green).

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产品信息

MA5-37127

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

5 µL/1x10^6 cells

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

PLK1T210-C2

抗原

A synthetic phospho-peptide corresponding to residues surrounding Thr210 of human phospho PLK1.

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偶联物

APC APC APC

激发/发射光谱

651/660 nm 查看光谱

形式

Liquid

纯化类型

Protein A/G

保存液

PBS with 0.20% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2897061

靶标信息

PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cell cycle regulated protein kinase; PLK 1; PLK-1; polo (Drosophia)-like kinase; polo like kinase; polo-like kinase; Polo-like kinase 1; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14

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基因别名: PLK; PLK1; STPK13

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UniProt ID: (Human) P53350

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Entrez Gene ID: (Human) 5347

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功能

protein kinase activity protein serine/threonine kinase activity protein binding ATP binding microtubule binding anaphase-promoting complex binding kinase activity protein kinase binding non-receptor serine/threonine protein kinase protein modifying enzyme

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