Product References
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
Bioactive materials
Guo Y,Mei F,Huang Y,Ma S,Wei Y,Zhang X,Xu M,He Y,Heng BC,Chen L,Deng X
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Sat Jan 01 00:00:00 EST 2022
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
Bioactive materials
Guo Y,Mei F,Huang Y,Ma S,Wei Y,Zhang X,Xu M,He Y,Heng BC,Chen L,Deng X
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Sat Jan 01 00:00:00 EST 2022
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
Bioactive materials
Guo Y,Mei F,Huang Y,Ma S,Wei Y,Zhang X,Xu M,He Y,Heng BC,Chen L,Deng X
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Sat Jan 01 00:00:00 EST 2022
Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development.
eLife
Ma J,Bi L,Spurlin J,Lwigale P
44-722G was used in Immunohistochemistry (Paraffin) to suggest that Npnt augments cell migration into the presumptive cornea extracellular matrix by functioning as a substrate for Itgα8-positive pNC cells.
Thu Mar 03 00:00:00 EST 2022
Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development.
eLife
Ma J,Bi L,Spurlin J,Lwigale P
44-722G was used in Immunohistochemistry (Paraffin) to suggest that Npnt augments cell migration into the presumptive cornea extracellular matrix by functioning as a substrate for Itgα8-positive pNC cells.
Thu Mar 03 00:00:00 EST 2022
Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity.
The Journal of cell biology
Fauser J,Huyot V,Matsche J,Szynal BN,Alexeev Y,Kota P,Karginov AV
44-722G was used in Western Blot to identify specific transient morphodynamic processes induced by Shp2 and determined the role of individual signaling pathways downstream of Shp2 in regulating these events.
Mon Aug 01 00:00:00 EDT 2022
CK2β Is a Gatekeeper of Focal Adhesions Regulating Cell Spreading.
Frontiers in molecular biosciences
Filhol O,Hesse AM,Bouin AP,Albigès-Rizo C,Jeanneret F,Battail C,Pflieger D,Cochet C
44-722G was used in Immunocytochemistry to show that decreased expression of CK2β in MCF10A mammary epithelial cells triggers the phosphorylation of a number of proteins on tyrosine residues and promotes the striking activation of the FAK1-Src-PAX1 signaling pathway.
Tue Jul 19 00:00:00 EDT 2022
Inhibition of Metastasis by Polypyridyl Ru(II) Complexes through Modification of Cancer Cell Adhesion - In Vitro Functional and Molecular Studies.
Journal of medicinal chemistry
Gurgul I,Janczy-Cempa E,Mazuryk O,Lekka M,Łomzik M,Suzenet F,Gros PC,Brindell M
44-722G was used in Western Blotting to assess the impact of polypyridyl Ru(II) complexes on various aspects of cancer cell behavior, including inhibiting cell detachment, migration, invasion, transmigration, re-adhesion, and increasing cell elasticity, while also affecting the activity of integrins and upregulating the expression of focal adhesion components.
Thu Aug 11 00:00:00 EDT 2022
EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.
EMBO reports
Zink J,Frye M,Frömel T,Carlantoni C,John D,Schreier D,Weigert A,Laban H,Salinas G,Stingl H,Günther L,Popp R,Hu J,Vanhollebeke B,Schmidt H,Acker-Palmer A,Renné T,Fleming I,Benz PM
44-722G was used in Immunocytochemistry-immunoflourescence to investigate the role of Ena/VASP proteins in angiogenesis.
Wed Feb 03 00:00:00 EST 2021
EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.
EMBO reports
Zink J,Frye M,Frömel T,Carlantoni C,John D,Schreier D,Weigert A,Laban H,Salinas G,Stingl H,Günther L,Popp R,Hu J,Vanhollebeke B,Schmidt H,Acker-Palmer A,Renné T,Fleming I,Benz PM
44-722G was used in Immunocytochemistry-immunoflourescence to investigate the role of Ena/VASP proteins in angiogenesis.
Wed Feb 03 00:00:00 EST 2021
The proprotein convertase furin inhibits IL-13-induced inflammation in airway smooth muscle by regulating integrin-associated signaling complexes.
American journal of physiology. Lung cellular and molecular physiology
Wu Y,Huang Y,Zhang W,Gunst SJ
44-722G was used in Western Blotting to demonstrate that furin inhibits inflammation in airway smooth muscle induced by IL-13 and that the anti-inflammatory effects of furin are mediated by activating integrin proteins and integrin-associated signaling complexes that regulate Akt-mediated pathways to the nucleus.
Thu Jul 01 00:00:00 EDT 2021
Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19.
Journal of cell science
Majstrowicz K,Honnert U,Nikolaus P,Schwarz V,Oeding SJ,Hemkemeyer SA,Bähler M
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Sat May 15 00:00:00 EDT 2021
Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19.
Journal of cell science
Majstrowicz K,Honnert U,Nikolaus P,Schwarz V,Oeding SJ,Hemkemeyer SA,Bähler M
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Sat May 15 00:00:00 EDT 2021
Integrin-linked kinase tunes cell-cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFβ1.
Molecular biology of the cell
Kilinc AN,Han S,Barrett LA,Anandasivam N,Nelson CM
44-722G was used in Western Blot to investigate the molecular signalling downstream of matrix stiffness that regulates the phenotypic switch in response to TGFβ1.
Mon Mar 01 00:00:00 EST 2021
Integrin-linked kinase tunes cell-cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFβ1.
Molecular biology of the cell
Kilinc AN,Han S,Barrett LA,Anandasivam N,Nelson CM
44-722G was used in Western Blot to investigate the molecular signalling downstream of matrix stiffness that regulates the phenotypic switch in response to TGFβ1.
Mon Mar 01 00:00:00 EST 2021
Cholecystokinin Receptor Antagonist Improves Efficacy of Chemotherapy in Murine Models of Pancreatic Cancer by Altering the Tumor Microenvironment.
Cancers
Malchiodi ZX,Cao H,Gay MD,Safronenka A,Bansal S,Tucker RD,Weinberg BA,Cheema A,Shivapurkar N,Smith JP
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Thu Sep 30 00:00:00 EDT 2021
Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling.
Frontiers in immunology
Arts JJG,Mahlandt EK,Schimmel L,Grönloh MLB,van der Niet S,Klein BJAM,Fernandez-Borja M,van Geemen D,Huveneers S,van Rijssel J,Goedhart J,van Buul JD
44-722G was used in Immunohistochemistry-immunofluorescence to show that focal adhesions mark the basolateral migration path of neutrophils.
Mon Oct 25 00:00:00 EDT 2021
Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling.
Frontiers in immunology
Arts JJG,Mahlandt EK,Schimmel L,Grönloh MLB,van der Niet S,Klein BJAM,Fernandez-Borja M,van Geemen D,Huveneers S,van Rijssel J,Goedhart J,van Buul JD
44-722G was used in Immunohistochemistry-immunofluorescence to show that focal adhesions mark the basolateral migration path of neutrophils.
Mon Oct 25 00:00:00 EDT 2021
Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation.
Molecular cancer
Weiße J,Rosemann J,Müller L,Kappler M,Eckert AW,Glaß M,Misiak D,Hüttelmaier S,Ballhausen WG,Hatzfeld M,Haemmerle M,Gutschner T
44-722G was used in Western Blot to show that reduction of LCK activity increased the formation of adherens junctions and induced cell differentiation.
Fri Jun 11 00:00:00 EDT 2021
Inhibiting FAK-Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells.
Cancers
Mousson A,Legrand M,Steffan T,Vauchelles R,Carl P,Gies JP,Lehmann M,Zuber G,De Mey J,Dujardin D,Sick E,Rondé P
44-722G was used in Immunocytochemistry to show that targeting FAK-paxillin interactions could be a potential therapeutic strategy to prevent metastasis formation, and molecules targeting this interface could be alternative to inhibitors of FAK kinase activity which display unexpected effects.
Wed Apr 14 00:00:00 EDT 2021
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Development (Cambridge, England)
Schimmel L,Fukuhara D,Richards M,Jin Y,Essebier P,Frampton E,Hedlund M,Dejana E,Claesson-Welsh L,Gordon E
44-722G was used in Immunocytochemistry to demonstrate that c-Src signaling at specified endothelial cell membrane compartments control vascular processes in a tissue- and context-dependent manner.
Mon Apr 06 00:00:00 EDT 2020
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Development (Cambridge, England)
Schimmel L,Fukuhara D,Richards M,Jin Y,Essebier P,Frampton E,Hedlund M,Dejana E,Claesson-Welsh L,Gordon E
44-722G was used in Immunocytochemistry to demonstrate that c-Src signaling at specified endothelial cell membrane compartments control vascular processes in a tissue- and context-dependent manner.
Mon Apr 06 00:00:00 EDT 2020
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Development (Cambridge, England)
Schimmel L,Fukuhara D,Richards M,Jin Y,Essebier P,Frampton E,Hedlund M,Dejana E,Claesson-Welsh L,Gordon E
44-722G was used in Immunocytochemistry to demonstrate that c-Src signaling at specified endothelial cell membrane compartments control vascular processes in a tissue- and context-dependent manner.
Mon Apr 06 00:00:00 EDT 2020
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Development (Cambridge, England)
Schimmel L,Fukuhara D,Richards M,Jin Y,Essebier P,Frampton E,Hedlund M,Dejana E,Claesson-Welsh L,Gordon E
44-722G was used in Immunocytochemistry to demonstrate that c-Src signaling at specified endothelial cell membrane compartments control vascular processes in a tissue- and context-dependent manner.
Mon Apr 06 00:00:00 EDT 2020
S100A4 is activated by RhoA and catalyses the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle.
The Journal of physiology
Zhang W,Gunst SJ
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Thu Oct 01 00:00:00 EDT 2020
S100A4 is activated by RhoA and catalyses the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle.
The Journal of physiology
Zhang W,Gunst SJ
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Thu Oct 01 00:00:00 EDT 2020
Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt.
American journal of physiology. Lung cellular and molecular physiology
Huang Y,Gunst SJ
44-722G was used in Proximity Ligation Assay (PLA) to describe a novel molecular mechanism for transduction of mechanical and humoral stimuli within integrin signaling complexes to regulate phenotype expression in airway smooth muscle.
Fri May 01 00:00:00 EDT 2020
Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt.
American journal of physiology. Lung cellular and molecular physiology
Huang Y,Gunst SJ
44-722G was used in Proximity Ligation Assay (PLA) to describe a novel molecular mechanism for transduction of mechanical and humoral stimuli within integrin signaling complexes to regulate phenotype expression in airway smooth muscle.
Fri May 01 00:00:00 EDT 2020
DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis.
Journal of cell science
van der Stoel M,Schimmel L,Nawaz K,van Stalborch AM,de Haan A,Klaus-Bergmann A,Valent ET,Koenis DS,van Nieuw Amerongen GP,de Vries CJ,de Waard V,Gloerich M,van Buul JD,Huveneers S
44-722G was used in Immunocytochemistry to reveal that the focal adhesion protein deleted-in-liver-cancer 1 (DLC1) is a direct transcriptional target of the activated YAP/TAZ-TEAD complex.
Wed Feb 12 00:00:00 EST 2020
Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells.
Cancers
Lee Y,Finch-Edmondson M,Cognart H,Zhu B,Song H,Low BC,Sudol M
44-722G was used in Immunocytochemistry-immunoflourescence to identify common and unique transcription signatures of YAP and TAZ in gastric cancer cells, as well as a dominant role for YAP over TAZ in the control of cell-substrate adhesion.
Mon Dec 07 00:00:00 EST 2020
Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation.
Cell reports
Chen K,Jiao X,Di Rocco A,Shen D,Xu S,Ertel A,Yu Z,Di Sante G,Wang M,Li Z,Pestell TG,Casimiro MC,Skordalakes E,Achilefu S,Pestell RG
44-722G was used in Immunohistochemistry-immunofluorescence to show that Akt1-mediated phosphorylation of downstream substrates in the mammary gland is reduced by cyclin D1 genetic deletion and is induced by mammary-gland-targeted cyclin D1 overexpression.
Tue Sep 15 00:00:00 EDT 2020
Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity.
eLife
Shaaya M,Fauser J,Zhurikhina A,Conage-Pough JE,Huyot V,Brennan M,Flower CT,Matsche J,Khan S,Natarajan V,Rehman J,Kota P,White FM,Tsygankov D,Karginov AV
44-722G was used in Western Blot to demonstrate efficient regulation of the kinase and identify temporally distinct signaling responses ranging from seconds to minutes.
Wed Sep 23 00:00:00 EDT 2020
Coupling of β2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis.
Nature cell biology
Jaumouillé V,Cartagena-Rivera AX,Waterman CM
44-722G was used in Immunocytochemistry-immunoflourescence to investigate whether mechanical coupling of αMβ2 integrin to the actin cytoskeleton mediates phagocytosis.
Fri Nov 01 00:00:00 EDT 2019
Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861.
Cancer research
Pedrosa AR,Bodrug N,Gomez-Escudero J,Carter EP,Reynolds LE,Georgiou PN,Fernandez I,Lees DM,Kostourou V,Alexopoulou AN,Batista S,Tavora B,Serrels B,Parsons M,Iskratsch T,Hodivala-Dilke KM
44-722G was used in Western Blotting to establish the differential requirements of EC-FAK-Y397 and EC-FAK-Y861-phosphorylation in the regulation of EC-signalling and tumor angiogenesis in vivo.
Sun Sep 01 00:00:00 EDT 2019
Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells.
Stem cells (Dayton, Ohio)
Godoy-Parejo C,Deng C,Liu W,Chen G
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunocytochemistry
Thu Aug 01 00:00:00 EDT 2019
Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells.
Stem cells (Dayton, Ohio)
Godoy-Parejo C,Deng C,Liu W,Chen G
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunocytochemistry
Thu Aug 01 00:00:00 EDT 2019
Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells.
Stem cells (Dayton, Ohio)
Godoy-Parejo C,Deng C,Liu W,Chen G
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunocytochemistry
Thu Aug 01 00:00:00 EDT 2019
Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells.
Stem cells (Dayton, Ohio)
Godoy-Parejo C,Deng C,Liu W,Chen G
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunocytochemistry
Thu Aug 01 00:00:00 EDT 2019
A unique role for clathrin light chain A in cell spreading and migration.
Journal of cell science
Tsygankova OM,Keen JH
44-722G was used in Western Blotting to comprise the first identification of CLCa-specific functions, with implications for normal and neoplastic integrin-based signaling and cell migration.
Wed May 15 00:00:00 EDT 2019
Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases.
American journal of physiology. Gastrointestinal and liver physiology
Osborne N,Sundseth R,Gay MD,Cao H,Tucker RD,Nadella S,Wang S,Liu X,Kroemer A,Sutton L,Cato A,Smith JP
44-722G was used in Western Blotting to investigate the effects of lone and combined treatment of polyclonal antibody stimulator, an anti-gastrin cancer vaccine, on pancreatic cancer growth, metastases, and the tumor microenvironment.
Fri Nov 01 00:00:00 EDT 2019
Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma.
Scientific reports
Rezey AC,Gerlach BD,Wang R,Liao G,Tang DD
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunocytochemistry
Fri May 17 00:00:00 EDT 2019
Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression.
Scientific reports
Dorland YL,Cornelissen AS,Kuijk C,Tol S,Hoogenboezem M,van Buul JD,Nolte MA,Voermans C,Huveneers S
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunocytochemistry
Mon Oct 07 00:00:00 EDT 2019
Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response.
Cell chemical biology
Klomp JE,Shaaya M,Matsche J,Rebiai R,Aaron JS,Collins KB,Huyot V,Gonzalez AM,Muller WA,Chew TL,Malik AB,Karginov AV
44-722G was used in Western Blot to control tyrosine kinase SRC activation to investigate endothelial barrier enhancement via SRC required phosphorylation of VE cadherin at Y731.
Thu Aug 15 00:00:00 EDT 2019
Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest.
Developmental cell
Roycroft A,Szabó A,Bahm I,Daly L,Charras G,Parsons M,Mayor R
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunocytochemistry
Mon Jun 04 00:00:00 EDT 2018
Cell adhesion is regulated by CDK1 during the cell cycle.
The Journal of cell biology
Jones MC,Askari JA,Humphries JD,Humphries MJ
44-722G was used in Western Blotting to demonstrate that cyclin-dependent kinase 1 mediates the link between the cell cycle machinery and the regulation of cell adhesion to the extracellular matrix.
Mon Sep 03 00:00:00 EDT 2018
Replication of biocompatible, nanotopographic surfaces.
Scientific reports
Sun X,Hourwitz MJ,Baker EM,Schmidt BUS,Losert W,Fourkas JT
44-722G was used in Immunocytochemistry-immunoflourescence to introduce a method for rapid, reproducible production of biocompatible, rigid, acrylic nanotopographic surfaces, and for the functionalisation of the surfaces with adhesion-promoting molecules for cell experiments.
Fri Jan 12 00:00:00 EST 2018
Non-muscle (NM) myosin heavy chain phosphorylation regulates the formation of NM myosin filaments, adhesome assembly and smooth muscle contraction.
The Journal of physiology
Zhang W,Gunst SJ
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Sat Jul 01 00:00:00 EDT 2017
Distinct focal adhesion protein modules control different aspects of mechanotransduction.
Journal of cell science
Stutchbury B,Atherton P,Tsang R,Wang DY,Ballestrem C
44-722G was used in Immunocytochemistry to show that the focal adhesion is composed of different functional modules that separately control mechanosensing and the cellular mechano-response.
Mon May 01 00:00:00 EDT 2017
Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor.
Journal of cell science
Freeman SA,Christian S,Austin P,Iu I,Graves ML,Huang L,Tang S,Coombs D,Gold MR,Roskelley CD
44-722G was used in western blot to elucidate initiation of directional invasion via the action of Rap1 GTPase as a tension sensor by applied stretch
Sun Jan 01 00:00:00 EST 2017
Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.
Molecular biology of the cell
Mekhdjian AH,Kai F,Rubashkin MG,Prahl LS,Przybyla LM,McGregor AL,Bell ES,Barnes JM,DuFort CC,Ou G,Chang AC,Cassereau L,Tan SJ,Pickup MW,Lakins JN,Ye X,Davidson MW,Lammerding J,Odde DJ,Dunn AR,Weaver VM
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Thu Jun 01 00:00:00 EDT 2017
Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.
Small GTPases
Farrugia AJ,Calvo F
44-722G was used in immunocytochemistry to study cancer-associated fibroblasts and Cdc42EP3 function regulated by Cdc42
Mon Jan 02 00:00:00 EST 2017
FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly.
Nature cell biology
Nader GP,Ezratty EJ,Gundersen GG
44722G was used in western blot to investigate how recycled integrins assemble into new adhesions
Sun May 01 00:00:00 EDT 2016
Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy.
The Journal of clinical investigation
Tomas NM,Hoxha E,Reinicke AT,Fester L,Helmchen U,Gerth J,Bachmann F,Budde K,Koch-Nolte F,Zahner G,Rune G,Lambeau G,Meyer-Schwesinger C,Stahl RA
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Fri Jul 01 00:00:00 EDT 2016
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.
The Journal of cell biology
Horton ER,Humphries JD,Stutchbury B,Jacquemet G,Ballestrem C,Barry ST,Humphries MJ
44-722G was used in immunocytochemistry and western blot to determine how modulation of FAK and Src adhesion signalling occurs without the need for adhesion complex composition
Mon Feb 01 00:00:00 EST 2016
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.
The Journal of cell biology
Horton ER,Humphries JD,Stutchbury B,Jacquemet G,Ballestrem C,Barry ST,Humphries MJ
44-722G was used in immunocytochemistry and western blot to determine how modulation of FAK and Src adhesion signalling occurs without the need for adhesion complex composition
Mon Feb 01 00:00:00 EST 2016
Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.
The Journal of cell biology
Kumar A,Ouyang M,Van den Dries K,McGhee EJ,Tanaka K,Anderson MD,Groisman A,Goult BT,Anderson KI,Schwartz MA
44-722G was used in immunocytochemistry to learn the revelation of novel features of focal adhesion force transmission and mechanosensitivity by talin tension sensor
Mon May 09 00:00:00 EDT 2016
The Lhx9-integrin pathway is essential for positioning of the proepicardial organ.
Development (Cambridge, England)
Tandon P,Wilczewski CM,Williams CE,Conlon FL
44-722G was used in immunohistochemistry to examine the contribution of the Lhx9-integrin-paxillin pathway to proepicardial organ positioning and epicardial formation
Tue Mar 01 00:00:00 EST 2016
Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae.
Molecular biology of the cell
Zimnicka AM,Husain YS,Shajahan AN,Sverdlov M,Chaga O,Chen Z,Toth PT,Klomp J,Karginov AV,Tiruppathi C,Malik AB,Minshall RD
44-722G was used in Western Blotting to study the role of Src-dependent, Caveloin 1 phosphorylation at Tyrosine-14.
Fri Jul 01 00:00:00 EDT 2016
MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis.
Molecular biology of the cell
Oudin MJ,Miller MA,Klazen JA,Kosciuk T,Lussiez A,Hughes SK,Tadros J,Bear JE,Lauffenburger DA,Gertler FB
44722G was used in immunocytochemistry to investigate the crosstalk among MenaINV, RTKs, and integrins
Sat Oct 15 00:00:00 EDT 2016
Cellular adhesome screen identifies critical modulators of focal adhesion dynamics, cellular traction forces and cell migration behaviour.
Scientific reports
Fokkelman M,Balcıoğlu HE,Klip JE,Yan K,Verbeek FJ,Danen EH,van de Water B
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Wed Aug 17 00:00:00 EDT 2016
Cellular adhesome screen identifies critical modulators of focal adhesion dynamics, cellular traction forces and cell migration behaviour.
Scientific reports
Fokkelman M,Balcıoğlu HE,Klip JE,Yan K,Verbeek FJ,Danen EH,van de Water B
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Wed Aug 17 00:00:00 EDT 2016
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.
eLife
Theodosiou M,Widmaier M,Böttcher RT,Rognoni E,Veelders M,Bharadwaj M,Lambacher A,Austen K,Müller DJ,Zent R,Fässler R
44-722G was used in western blot to determine the role of Kindlin-2 tp activate integrins by cooperating with talin and induction of cell spreading by directly binding paxillin
Wed Jan 27 00:00:00 EST 2016
Highly Multiplexed Imaging Uncovers Changes in Compositional Noise within Assembling Focal Adhesions.
PloS one
Harizanova J,Fermin Y,Malik-Sheriff RS,Wieczorek J,Ickstadt K,Grecco HE,Zamir E
44-722G was used in immunocytochemistry study the assembly of integrin adhesome protein complexes
Thu Jul 27 00:00:00 EDT 2017
Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions.
Nature cell biology
Case LB,Baird MA,Shtengel G,Campbell SL,Hess HF,Davidson MW,Waterman CM
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Wed Jul 01 00:00:00 EDT 2015
Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions.
Nature cell biology
Case LB,Baird MA,Shtengel G,Campbell SL,Hess HF,Davidson MW,Waterman CM
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Wed Jul 01 00:00:00 EDT 2015
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly.
Nature cell biology
Horton ER,Byron A,Askari JA,Ng DHJ,Millon-Frémillon A,Robertson J,Koper EJ,Paul NR,Warwood S,Knight D,Humphries JD,Humphries MJ
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Tue Dec 01 00:00:00 EST 2015
Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons.
The Journal of cell biology
Jiang J,Zhang ZH,Yuan XB,Poo MM
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Mon Jun 08 00:00:00 EDT 2015
The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions.
Journal of cell science
Balcioglu HE,van Hoorn H,Donato DM,Schmidt T,Danen EH
44-722G was used in western blot to investigate the effect of altering the abundance of fibronectin-binding integrins in cell-matrix adhesions on the spatiotemporal organization of force transmission.
Wed Apr 01 00:00:00 EDT 2015
Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.
Nature communications
Robertson J,Jacquemet G,Byron A,Jones MC,Warwood S,Selley JN,Knight D,Humphries JD,Humphries MJ
44-722G was used in western blot to study phosphorylation events at sites of adhesion
Fri Feb 13 00:00:00 EST 2015
Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration.
Scientific reports
Wu JC,Chen YC,Kuo CT,Wenshin Yu H,Chen YQ,Chiou A,Kuo JC
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Fri Dec 18 00:00:00 EST 2015
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.
Cell reports
Calvo F,Ranftl R,Hooper S,Farrugia AJ,Moeendarbary E,Bruckbauer A,Batista F,Charras G,Sahai E
44-722G was used in western blot to study Cdc42EP3/BORG2 in cancer-associated fibroblasts
Tue Dec 29 00:00:00 EST 2015
Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol.
eLife
Hoffmann JE,Fermin Y,Stricker RL,Ickstadt K,Zamir E
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Tue Jun 03 00:00:00 EDT 2014
Homocysteine induces serum amyloid A3 in osteoblasts via unlocking RGD-motifs in collagen.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Thaler R,Zwerina J,Rumpler M,Spitzer S,Gamsjaeger S,Paschalis EP,Klaushofer K,Varga F
44-722G was used in western blot to study the effect of Hcys on expression of SAA3 in osteoblasts.
Fri Feb 01 00:00:00 EST 2013
A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation.
Journal of cell science
Miller NL,Lawson C,Kleinschmidt EG,Tancioni I,Uryu S,Schlaepfer DD
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Fri Nov 01 00:00:00 EDT 2013
Slack length reduces the contractile phenotype of the Swine carotid artery.
Journal of vascular research
Rembold CM,Garvey SM,Tejani AD
44-722G was used in western blot to study the contractile state of arterial smooth muscle.
Fri Sep 27 00:00:00 EDT 2013
Effective treatment of edema and endothelial barrier dysfunction with imatinib.
Circulation
Aman J,van Bezu J,Damanafshan A,Huveneers S,Eringa EC,Vogel SM,Groeneveld AB,Vonk Noordegraaf A,van Hinsbergh VW,van Nieuw Amerongen GP
44-722G was used in Immunocytochemistry-immunoflourescence to demonstrate that imatinib prevents endothelial barrier dysfunction and edema formation via inhibition of Arg.
Tue Dec 04 00:00:00 EST 2012
RhoB regulates uPAR signalling.
Journal of cell science
Alfano D,Ragno P,Stoppelli MP,Ridley AJ
Tue May 15 00:00:00 EDT 2012
Specific β-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells.
The Journal of biological chemistry
Jeanes AI,Wang P,Moreno-Layseca P,Paul N,Cheung J,Tsang R,Akhtar N,Foster FM,Brennan K,Streuli CH
Fri Jul 13 00:00:00 EDT 2012
Focal adhesion proteins talin-1 and vinculin negatively affect paxillin phosphorylation and limit retroviral infection.
Journal of molecular biology
Brown C,Morham SG,Walsh D,Naghavi MH
44-722G was used in western blot to study talin- and vinculin during retroviral infection.
Fri Jul 29 00:00:00 EDT 2011
Tissue length modulates "stimulated actin polymerization," force augmentation, and the rate of swine carotid arterial contraction.
American journal of physiology. Cell physiology
Tejani AD,Walsh MP,Rembold CM
44-722G was used in western blot to alter stimulated actin polymerization by adjusting tissue length and measure the effect on force augmentation.
Thu Dec 01 00:00:00 EST 2011
Force- and Ca²⁺-dependent internalization of integrins in cultured endothelial cells.
Journal of cell science
Kiyoshima D,Kawakami K,Hayakawa K,Tatsumi H,Sokabe M
Tue Nov 15 00:00:00 EST 2011
PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo.
Breast cancer research and treatment
Ma JG,Huang H,Chen SM,Chen Y,Xin XL,Lin LP,Ding J,Liu H,Meng LH
44-722G was used in western blot to identify the Src kinase inhibitor, PH006, and explore its activity and mechanism of action in human breast cancer.
Tue Nov 01 00:00:00 EDT 2011
Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway.
Journal of cell science
Nethe M,Anthony EC,Fernandez-Borja M,Dee R,Geerts D,Hensbergen PJ,Deelder AM,Schmidt G,Hordijk PL
44-722G was used in Immunocytochemistry-immunoflourescence to show that Rac1 binds caveolin-1 (Cav1), and that Rac1 activity promotes Cav1 accumulation at Rac1-positive peripheral adhesions.
Tue Jun 01 00:00:00 EDT 2010
c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.
The Journal of biological chemistry
Jiao X,Katiyar S,Willmarth NE,Liu M,Ma X,Flomenberg N,Lisanti MP,Pestell RG
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Fri Mar 12 00:00:00 EST 2010
c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.
The Journal of biological chemistry
Jiao X,Katiyar S,Willmarth NE,Liu M,Ma X,Flomenberg N,Lisanti MP,Pestell RG
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Fri Mar 12 00:00:00 EST 2010
Loss of SNAP29 impairs endocytic recycling and cell motility.
PloS one
Rapaport D,Lugassy Y,Sprecher E,Horowitz M
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Thu Mar 18 00:00:00 EDT 2010
Loss of SNAP29 impairs endocytic recycling and cell motility.
PloS one
Rapaport D,Lugassy Y,Sprecher E,Horowitz M
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Immunofluorescence
Thu Mar 18 00:00:00 EDT 2010
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
van Miltenburg MH,Lalai R,de Bont H,van Waaij E,Beggs H,Danen EH,van de Water B
44-722G was used in immunohistochemistry - paraffin section and western blot to determine the role and mechanism of focal adhesion kinase-mediated signaling in mammary gland development and differentiation.
Thu Oct 01 00:00:00 EDT 2009
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
van Miltenburg MH,Lalai R,de Bont H,van Waaij E,Beggs H,Danen EH,van de Water B
44-722G was used in immunohistochemistry - paraffin section and western blot to determine the role and mechanism of focal adhesion kinase-mediated signaling in mammary gland development and differentiation.
Thu Oct 01 00:00:00 EDT 2009
An adaptor role for cytoplasmic Sam68 in modulating Src activity during cell polarization.
Molecular and cellular biology
Huot ME,Brown CM,Lamarche-Vane N,Richard S
44-722G was used in western blot to demonstrate that Sam68-deficient cells exhibit loss of cell polarity and cell migration
Wed Apr 01 00:00:00 EDT 2009
Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.
BMC cancer
Sachdev S,Bu Y,Gelman IH
44-722G was used in western blot to review the functional consequences of interactions between focal adhesion kinase and Src are protein tyrosine kinases
Mon Jan 12 00:00:00 EST 2009
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
Nature cell biology
Pinner S,Sahai E
44-722G was used in immunocytochemistry to elucidate how PDK1 regulates cortical acto-myosin and cell motility
Fri Feb 01 00:00:00 EST 2008
Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase.
Molecular biology of the cell
Jiao X,Katiyar S,Liu M,Mueller SC,Lisanti MP,Li A,Pestell TG,Wu K,Ju X,Li Z,Wagner EF,Takeya T,Wang C,Pestell RG
44-722G was used in immunocytochemistry to determine the role of c-Jun in cellular invasion
Tue Apr 01 00:00:00 EDT 2008
Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contraction.
American journal of physiology. Cell physiology
Rembold CM,Tejani AD,Ripley ML,Han S
44-722G was used in western blot to study the role of paxillin in the regulation of actin polymerization
Sat Sep 01 00:00:00 EDT 2007
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Molecular and cellular biology
Cai X,Li M,Vrana J,Schaller MD
Sat Apr 01 00:00:00 EST 2006
Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST.
The Journal of biological chemistry
Lu TJ,Lai WY,Huang CY,Hsieh WJ,Yu JS,Hsieh YJ,Chang WT,Leu TH,Chang WC,Chuang WJ,Tang MJ,Chen TY,Lu TL,Lai MD
Published figure using Phospho-Paxillin (Tyr118) polyclonal antibody (Product # 44-722G) in Western Blot
Fri Dec 15 00:00:00 EST 2006
p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV.
The Journal of biological chemistry
Sanders MA,Basson MD
44-722G was used in western blot to study the essential role for Caco-2 intestinal epithelial cell spreading and migration on collagen IV by p130cas but not paxillin
Fri Jun 24 00:00:00 EDT 2005
Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling.
The Journal of biological chemistry
Liu Y,Yerushalmi GM,Grigera PR,Parsons JT
Fri Mar 11 00:00:00 EST 2005
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.
The Journal of biological chemistry
Nakamura K,Yano H,Uchida H,Hashimoto S,Schaefer E,Sabe H
Fri Sep 01 00:00:00 EDT 2000
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.
The Journal of biological chemistry
Nakamura K,Yano H,Uchida H,Hashimoto S,Schaefer E,Sabe H
Fri Sep 01 00:00:00 EDT 2000
