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Invitrogen
Phospho-Phospholamban (Ser16) Recombinant Rabbit Monoclonal Antibody (HL1710)
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Phospho-Phospholamban (Ser16) Antibody (MA5-46899) in WB
Western blot analysis of Phospho-Phospholamban (Ser16) in untreated (–) and treated (+) mouse tissue extract (50 µg) separated by 15% SDS-PAGE. Membrane was blotted with Phospho-Phospholamban (Ser16) Monoclonal antibody (Product # MA5-46899) using a dilution of 1:1,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody.
产品信息
MA5-46899
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1710
抗原
Carrier-protein conjugated synthetic peptide surrounding phospho Ser16 of human phospholamban . The exact sequence is proprietary
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2937971
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiac CMH18; Cardiac phospholamban; PLB
基因别名: CMD1P; CMH18; PLB; PLN
UniProt ID: (Human) P26678, (Mouse) P61014
Entrez Gene ID: (Human) 5350, (Mouse) 18821
regulation of the force of heart contraction
calcium ion transport
cellular calcium ion homeostasis
Notch signaling pathway
regulation of heart contraction
response to zinc ion
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
response to testosterone
negative regulation of catalytic activity
negative regulation of heart contraction
cardiac muscle tissue development
protein homooligomerization
regulation of ryanodine-sensitive calcium-release channel activity
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in heart process
regulation of the force of heart contraction by cardiac conduction
regulation of calcium ion import
regulation of relaxation of muscle
blood circulation
negative regulation of heart rate
negative regulation of ATPase activity
response to insulin
regulation of cytosolic calcium ion concentration
regulation of calcium ion transport
negative regulation of calcium ion transport
relaxation of cardiac muscle
regulation of cardiac muscle cell membrane potential
negative regulation of calcium ion import
negative regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion binding
regulation of calcium-transporting ATPase activity
negative regulation of calcium-transporting ATPase activity
regulation of relaxation of cardiac muscle
negative regulation of calcium ion import into sarcoplasmic reticulum
regulation of cardiac conduction
