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Phospho-Separase (Ser1126) Antibody (PA5-12691) in IHC (P)
Immunohistochemistry analysis of Phospho-Separase (Ser1126) in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with Phospho-Separase (Ser1126) polyclonal antibody (Product # PA5-12691) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been e... View More
产品信息
PA5-12691
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1126 of human SEPARIN
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2101812
靶标信息
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Caspase-like protein ESPL1; extra spindle pole bodies 1, separase; extra spindle pole bodies homolog 1; extra spindle poles like 1; Extra spindle poles-like 1 protein; FLJ46492; Separase; Separin; separin, cysteine protease
基因别名: ESP1; ESPL1; KIAA0165; SEPA
UniProt ID: (Human) Q14674
Entrez Gene ID: (Human) 9700
mitotic sister chromatid segregation
meiotic spindle organization
cytokinesis
proteolysis
apoptotic process
establishment of mitotic spindle localization
homologous chromosome segregation
positive regulation of mitotic metaphase/anaphase transition
negative regulation of sister chromatid cohesion
meiotic chromosome separation
positive regulation of mitotic sister chromatid separation
