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产品信息
PMAD-140AP
产品规格
种属反应
Fruit fly
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 405-455 on D. melanogaster Mothers against dpp protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
靶标信息
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: apang; CG12399-PA; CG12399-PB; DWFC; hSMAD1; Mad-PA; Mad-PB; MADH5; mother against decapentaplegic; mother against Dpp; mothers against decapentaplegi; mothers against decapentaplegic; Mothers-against-decapentaplegic; Mothers-against-DPP-related-1; OTTHUMP00000220456; phospho-Smad; phosphorylated smad; phosphoSmad; Protein mothers against dpp; RE72705p; SMAD; SMAD5
基因别名: 2/23; apg; c28; CG12399; dMAD; Dmel\CG12399; Dmel_CG12399; E(zen)2; En(vvl); l(2)K00237; MAD; Mat; P-Mad; PMad; pSmad; Smad; Smad1
UniProt ID: (Fruit fly) P42003
Entrez Gene ID: (Fruit fly) 33529
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
ubiquitin protein ligase binding
sequence-specific DNA binding
I-SMAD binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
compound eye morphogenesis
transforming growth factor beta receptor signaling pathway
ventral cord development
imaginal disc-derived wing morphogenesis
imaginal disc-derived leg morphogenesis
histoblast morphogenesis
heart development
imaginal disc morphogenesis
imaginal disc-derived wing vein morphogenesis
anatomical structure morphogenesis
cell differentiation
BMP signaling pathway
ovarian follicle cell development
germ-line stem cell population maintenance
somatic stem cell population maintenance
trunk segmentation
germ-line stem cell division
R8 cell fate specification
regulation of cell differentiation
negative regulation of salivary gland boundary specification
positive regulation of synaptic growth at neuromuscular junction
positive regulation of transcription from RNA polymerase II promoter
wing disc anterior/posterior pattern formation
SMAD protein signal transduction
transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification
positive regulation of neuromuscular junction development
negative regulation of G1/S transition of mitotic cell cycle
