Product References
Common mouse models of tauopathy reflect early but not late human disease.
Molecular neurodegeneration
Wenger K,Viode A,Schlaffner CN,van Zalm P,Cheng L,Dellovade T,Langlois X,Bannon A,Chang R,Connors TR,Oakley D,Renard B,Rappsilber J,Hyman B,Steen H,Steen JA
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show that AD mouse models that overexpress human Tau using risk mutations are a suitable tool for testing drug candidates that aim to intervene in the early formation of insoluble Tau species promoted by increased phosphorylation of Tau.
Thu Feb 02 00:00:00 EST 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1060 was used in Western Blot to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 EDT 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1060 was used in Western Blot to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 EDT 2023
Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities.
Brain communications
Daniilidou M,Eroli F,Alanko V,Goikolea J,Latorre-Leal M,Rodriguez-Rodriguez P,Griffiths WJ,Wang Y,Pacciarini M,Brinkmalm A,Zetterberg H,Blennow K,Rosenberg A,Bogdanovic N,Winblad B,Kivipelto M,Ibghi D,Cedazo-Minguez A,Maioli S,Matton A
MN1060 was used in Immunohistochemistry-immunofluorescence to investigate 13 molecular markers representing key mechanisms underlying Alzheimer's disease pathogenesis in CSF from memory clinic patients without diagnosed hypertension, hypercholesterolaemia or diabetes nor other neurodegenerative disorders.
Sun Feb 04 00:00:00 EST 2024
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1060 was used in Western Blot to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 EDT 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1060 was used in Western Blot to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 EDT 2023
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
de Oliveira P,Cella C,Locker N,Ravindran KKG,Mendis A,Wafford K,Gilmour G,Dijk DJ,Winsky-Sommerer R
MN1060 was used in Western Blot to investigate whether trazodone, a licensed antidepressant with hypnotic efficacy in dementia, can reduce disease-related cellular pathways and improve memory and sleep in male rTg4510 mice with a tauopathy-like phenotype.
Wed Apr 20 00:00:00 EDT 2022
Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer's Patients: A Biphasic Regulation of Neurogenesis.
International journal of molecular sciences
Gil L,Chi-Ahumada E,Niño SA,Capdeville G,Méndez-Torres AM,Guerrero C,Rebolledo AB,Olazabal IM,Jiménez-Capdeville ME
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to find nuclear alterations in granular cells in autopsied human brains, detected by immunohistochemistry.
Tue Oct 25 00:00:00 EDT 2022
Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro.
Communications biology
Asada-Utsugi M,Uemura K,Ayaki T,T Uemura M,Minamiyama S,Hikiami R,Morimura T,Shodai A,Ueki T,Takahashi R,Kinoshita A,Urushitani M
MN1060 was used in Western Blot to suggest that DSB plays a pivotal role in AD-tau pathology and that the failure of DSB repair leads to tauopathy.
Wed Apr 13 00:00:00 EDT 2022
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response.
Journal of neuroinflammation
Manet C,Mansuroglu Z,Conquet L,Bortolin V,Comptdaer T,Segrt H,Bourdon M,Menidjel R,Stadler N,Tian G,Herit F,Niedergang F,Souès S,Buée L,Galas MC,Montagutelli X,Bonnefoy E
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry to show that ZIKV-infected mature neurons display an inability to stop viral replication in link with a delayed IFNB expression, accumulating pTau and overall reflecting tauopathy-like phenotype.
Tue Dec 20 00:00:00 EST 2022
Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion.
Journal of neuroscience research
Roqanian S,Ahmadian S,Nabavi SM,Pakdaman H,Shafiezadeh M,Goudarzi G,Shahpasand K
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to indicate that P-tau nuclear translocation results in p53-dependent apoptosis and nucleolar dispersion, which is consistent with neurodegeneration.
Fri Apr 01 00:00:00 EDT 2022
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models.
ACS chemical neuroscience
McMurray L,Macdonald JA,Ramakrishnan NK,Zhao Y,Williamson DW,Tietz O,Zhou X,Kealey S,Fagan SG,Smolek T,Cubinkova V,Žilka N,Spillantini MG,Tolkovsky AM,Goedert M,Aigbirhio FI
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to improve the development of PET imaging probes for visualizing tau pathology in transgenic models of neurodegeneration.
Wed Jun 02 00:00:00 EDT 2021
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
eLife
Zhang X,Zou L,Meng L,Xiong M,Pan L,Chen G,Zheng Y,Xiong J,Wang Z,Duong DM,Zhang Z,Cao X,Wang T,Tang L,Ye K,Zhang Z
MN1060 was used in Immunohistochemistry to demonstrate that Amphiphysin I mediates tau phosphorylation and synaptic dysfunction in Alzheimer's disease.
Fri May 21 00:00:00 EDT 2021
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
eLife
Zhang X,Zou L,Meng L,Xiong M,Pan L,Chen G,Zheng Y,Xiong J,Wang Z,Duong DM,Zhang Z,Cao X,Wang T,Tang L,Ye K,Zhang Z
MN1060 was used in Immunohistochemistry to demonstrate that Amphiphysin I mediates tau phosphorylation and synaptic dysfunction in Alzheimer's disease.
Fri May 21 00:00:00 EDT 2021
Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.
Brain communications
Haytural H,Jordà-Siquier T,Winblad B,Mulle C,Tjernberg LO,Granholm AC,Frykman S,Barthet G
MN1060 was used in Immunohistochemistry (Paraffin) to highlight the distinctive vulnerability of the outer molecular layer of the dentate gyrus and supports the notion of presynaptic failure in Alzheimer's disease.
Sat May 22 00:00:00 EDT 2021
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Alzheimer's & dementia (New York, N. Y.)
Omoluabi T,Torraville SE,Maziar A,Ghosh A,Power KD,Reinhardt C,Harley CW,Yuan Q
MN1060 was used in Western Blot to argue that variations in environmental experiences associated with differing LC activity patterns may account for individual susceptibility to development of AD in humans.
Tue Jan 11 00:00:00 EST 2022
Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease.
Progress in neurobiology
Xia Y,Wang ZH,Zhang Z,Liu X,Yu SP,Wang JZ,Wang XC,Ye K
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to show that delta-secretase cleaves BACE1, a rate-limiting protease in amyloid-β (Aβ) generation, escalating its enzymatic activity and enhancing senile plaques deposit in AD.
Wed Sep 01 00:00:00 EDT 2021
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.
Acta neuropathologica communications
Lam S,Petit F,Hérard AS,Boluda S,Eddarkaoui S,Guillermier M,Buée L,Duyckaerts C,Haïk S,Picq JL,Dhenain M
MN1060 was used in Immunohistochemistry, Western Blot to understand the cognitive repercussions of tau in individuals who do not develop cerebral haemorrhages.
Tue Oct 12 00:00:00 EDT 2021
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.
Acta neuropathologica communications
Lam S,Petit F,Hérard AS,Boluda S,Eddarkaoui S,Guillermier M,Buée L,Duyckaerts C,Haïk S,Picq JL,Dhenain M
MN1060 was used in Immunohistochemistry, Western Blot to understand the cognitive repercussions of tau in individuals who do not develop cerebral haemorrhages.
Tue Oct 12 00:00:00 EDT 2021
The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function.
Redox biology
Jaillard C,Ouechtati F,Clérin E,Millet-Puel G,Corsi M,Aït-Ali N,Blond F,Chevy Q,Gales L,Farinelli M,Dalkara D,Sahel JA,Portais JC,Poncer JC,Léveillard T
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to investigate the link between NXNL2 and tauopathies.
Thu Nov 25 00:00:00 EST 2021
IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer's Disease Associated With Brain Weight.
Frontiers in aging neuroscience
Winslow W,McDonough I,Tallino S,Decker A,Vural AS,Velazquez R
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to examine d the behavioral performance of 3xTg-AD mice in the IntelliCage o study mechanisms of pathogenesis and connect these mechanisms with cognitive decline.
Thu Apr 14 00:00:00 EDT 2022
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Acta neuropathologica communications
Miller LVC,Mukadam AS,Durrant CS,Vaysburd MJ,Katsinelos T,Tuck BJ,Sanford S,Sheppard O,Knox C,Cheng S,James LC,Coleman MP,McEwan WA
MN1060 was used in Western Blotting to ask whether tau assemblies share with classical pathogens the characteristic of particulate behaviour.
Fri Mar 12 00:00:00 EST 2021
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Molecular neurodegeneration
Bichmann M,Prat Oriol N,Ercan-Herbst E,Schöndorf DC,Gomez Ramos B,Schwärzler V,Neu M,Schlüter A,Wang X,Jin L,Hu C,Tian Y,Ried JS,Haberkant P,Gasparini L,Ehrnhoefer DE
MN1060 was used in ELISA to demonstrate that methylated Tau levels increase with Tau pathology stage in human AD samples as well as in a mouse model of Tauopathy.
Fri Jul 02 00:00:00 EDT 2021
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease.
Cell reports
Brigas HC,Ribeiro M,Coelho JE,Gomes R,Gomez-Murcia V,Carvalho K,Faivre E,Costa-Pereira S,Darrigues J,de Almeida AA,Buée L,Dunot J,Marie H,Pousinha PA,Blum D,Silva-Santos B,Lopes LV,Ribot JC
MN1060 was used in Western Blot to support the idea that cognition relies on a finely regulated balance of "inflammatory" cytokines derived from the meningeal immune system.
Tue Aug 31 00:00:00 EDT 2021
Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study.
International journal of molecular sciences
Ahmad F,Mein H,Jing Y,Zhang H,Liu P
MN1060 was used in Western Blot to investigate how behavioural functions, resting cerebral blood flow (CBF) and tau pathology change in PS19 mice at 2, 4, 6, 8 and 12 months of age in a single study under one experimental condition, allowing for the cumulative assessment of age- and genotype-dependent changes.
Wed Sep 08 00:00:00 EDT 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Acta neuropathologica communications
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Marcilla I,Marti-Andres G,Caballero MC,Riverol M,Tuñon MT,Fraser PE,Luquin MR
MN1060 was used in Immunohistochemistry to show that the involvement of amylin, pancreatic α-synuclein, Aβ, PrP and tau in the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson's disease.
Thu Apr 08 00:00:00 EDT 2021
Initiation of Parkinson's disease from gut to brain by δ-secretase.
Cell research
Ahn EH,Kang SS,Liu X,Chen G,Zhang Z,Chandrasekharan B,Alam AM,Neish AS,Cao X,Ye K
MN1060 was used in Immunohistochemistry to conclude that δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS.
Wed Jan 01 00:00:00 EST 2020
A Low Cost Antibody Signal Enhancer Improves Immunolabeling in Cell Culture, Primate Brain and Human Cancer Biopsy.
Neuroscience
Flores-Maldonado C,Albino-Sánchez ME,Rodríguez-Callejas JD,Estrada-Mondragon A,León-Galicia I,Maqueda-Alfaro R,Perez-Cruz C,Fuchs E,García-Carrancá A,Contreras RG,Missirlis F,Rosas-Arellano A
MN1060 was used in Immunohistochemistry to describe three new settings in which ASE improves the detection of a variety of antibodies applied on long-time stored non-human primate brain sections, cell culture monolayers and on squamous carcinomas retrieved from cervical cancer patients.
Wed Jul 15 00:00:00 EDT 2020
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy.
Biomedical optics express
Ni R,Chen Z,Gerez JA,Shi G,Zhou Q,Riek R,Nilsson KPR,Razansky D,Klohs J
MN1060 was used in Immunohistochemistry (Paraffin) to report a transcranial detection of tauopathy over the entire cortex of P301L tauopathy mice using large-field multifocal illumination (LMI) fluorescence microscopy technique and luminescent conjugated oligothiophenes.
Tue Sep 01 00:00:00 EDT 2020
Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation.
ASN neuro
Das R,Balmik AA,Chinnathambi S
MN1060 was used in Immunocytochemistry-immunoflourescence to check the neuroprotective function of Melatonin by MTT and LDH assay, where Melatonin inhibited the Tau aggregates-mediated cytotoxicity and membrane leakage in Neuro2A cells.
Wed Oct 06 00:00:00 EDT 2021
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Scientific reports
Dominguez-Meijide A,Vasili E,König A,Cima-Omori MS,Ibáñez de Opakua A,Leonov A,Ryazanov S,Zweckstetter M,Griesinger C,Outeiro TF
MN1060 was used in Western Blotting to assess the effects of different pharmacological interventions on the aggregation and internalization of tau and aSyn.
Thu Jul 30 00:00:00 EDT 2020
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature
Falcon B,Zivanov J,Zhang W,Murzin AG,Garringer HJ,Vidal R,Crowther RA,Newell KL,Ghetti B,Goedert M,Scheres SHW
MN1060 was used in Immunohistochemistry to provide a unifying neuropathological criterion for CTE, and support the hypothesis that the formation and propagation of distinct conformers of assembled tau underlie different neurodegenerative diseases.
Mon Apr 01 00:00:00 EDT 2019
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Brain : a journal of neurology
Mancuso R,Fryatt G,Cleal M,Obst J,Pipi E,Monzón-Sandoval J,Ribe E,Winchester L,Webber C,Nevado A,Jacobs T,Austin N,Theunis C,Grauwen K,Daniela Ruiz E,Mudher A,Vicente-Rodriguez M,Parker CA,Simmons C,Cash D,Richardson J,Jones DNC,Lovestone S,Gómez-Nicola D,Perry VH
MN1060 was used in Immunohistochemistry to tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 in the P301S mouse tauopathy model.
Tue Oct 01 00:00:00 EDT 2019
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Brain : a journal of neurology
Mancuso R,Fryatt G,Cleal M,Obst J,Pipi E,Monzón-Sandoval J,Ribe E,Winchester L,Webber C,Nevado A,Jacobs T,Austin N,Theunis C,Grauwen K,Daniela Ruiz E,Mudher A,Vicente-Rodriguez M,Parker CA,Simmons C,Cash D,Richardson J,Jones DNC,Lovestone S,Gómez-Nicola D,Perry VH
MN1060 was used in Immunohistochemistry to tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 in the P301S mouse tauopathy model.
Tue Oct 01 00:00:00 EDT 2019
Amylin as a potential link between type 2 diabetes and alzheimer disease.
Annals of neurology
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Riverol M,Marcilla I,de Andrea CE,Sánchez-Arias JA,Del Mar Carmona-Abellan M,Marti G,Erro ME,Martínez-Vila E,Tuñon MT,Luquin MR
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to assess ed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with Alzheimer's disease, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of Alzheimer's disease patients.
Tue Oct 01 00:00:00 EDT 2019
Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice.
Aging cell
Belfiore R,Rodin A,Ferreira E,Velazquez R,Branca C,Caccamo A,Oddo S
MN1060 was used in Immunohistochemistry to indicate a consistent and predictable progression of the AD-like pathology in female 3xTg-AD mice, and will facilitate the design of future studies using these mice.
Fri Feb 01 00:00:00 EST 2019
Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.
Journal of Alzheimer's disease : JAD
Regalado-Reyes M,Furcila D,Hernández F,Ávila J,DeFelipe J,León-Espinosa G
MN1060 was used in Immunohistochemistry-immunofluorescence to study the molecular and structural changes responsible for neurofibrillary tangle development.
Wed Sep 09 00:00:00 EDT 2020
Effects of Amylin Against Amyloid-β-Induced Tauopathy and Synapse Loss in Primary Neurons.
Journal of Alzheimer's disease : JAD
Gan Q,Yao H,Na H,Ballance H,Tao Q,Leung L,Tian H,Zhu H,Wolozin B,Qiu WQ
MN1060 was used in Immunocytochemistry-immunoflourescence to investigate the antagonism between amylin and amyloid-β peptide induced Alzheimer''s disease pathology in neurons, using both in vitro and in vivo mouse models.
Fri Oct 09 00:00:00 EDT 2020
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Frontiers in neuroanatomy
Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T
MN1060 was used in Western Blot to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.
Fri Oct 13 00:00:00 EDT 2023
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Frontiers in neuroanatomy
Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T
MN1060 was used in Western Blot to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.
Fri Oct 13 00:00:00 EDT 2023
In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain.
Prion
Nam WH,Choi YP
MN1060 was used in Immunocytochemistry-immunoflourescence to characterise how in vitro generated tau aggregates are conformationally distinct from parent seeds of Alzheimer's brain.
Tue Jan 01 00:00:00 EST 2019
Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Terreros-Roncal J,Flor-García M,Moreno-Jiménez EP,Pallas-Bazarra N,Rábano A,Sah N,van Praag H,Giacomini D,Schinder AF,Ávila J,Llorens-Martín M
MN1060 was used in Immunohistochemistry to study the therapeutic potential of applying chemoactivation to adult-born dentate granule cells in a mouse model of a neurodegenerative disease.
Wed Jul 17 00:00:00 EDT 2019
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports.
Acta neuropathologica communications
Schwab N,Grenier K,Hazrati LN
MN1060 was used in Immunohistochemistry to assess clinical presentation, neuropathological changes, load of DNA damage, morphological markers of cellular senescence, and expression of genes involved in DNA damage signaling, DNA repair, and cellular senescence including the senescence-associated secretory phenotype (SASP) in 38 professional athletes.
Thu Nov 14 00:00:00 EST 2019
N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain.
Acta neuropathologica communications
Schlegel K,Awwad K,Heym RG,Holzinger D,Doell A,Barghorn S,Jahn TR,Klein C,Mordashova Y,Schulz M,Gasparini L
MN1060 was used in Immunohistochemistry to identify four putative LGMN cleavage sites at Tau residues N167-, N255-, N296- and N368, using an in vitro enzymatic assay and non-targeted mass spectrometry.
Wed Nov 13 00:00:00 EST 2019
The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome.
Neuropathology and applied neurobiology
Milenkovic I,Jarc J,Dassler E,Aronica E,Iyer A,Adle-Biassette H,Scharrer A,Reischer T,Hainfellner JA,Kovacs GG
MN1060 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to suggest functional tau disturbance in DS brains during development, rather than axonal loss.
Sun Apr 01 00:00:00 EDT 2018
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
The Journal of biological chemistry
Falcon B,Noad J,McMahon H,Randow F,Goedert M
MN1060 was used in Immunofluorescence to determine how assembled tau seeds gain access to the cytosol and whether this access triggers cellular defenses in humans.
Fri Feb 16 00:00:00 EST 2018
Cryo-EM structures of tau filaments from Alzheimer's disease.
Nature
Fitzpatrick AWP,Falcon B,He S,Murzin AG,Murshudov G,Garringer HJ,Crowther RA,Ghetti B,Goedert M,Scheres SHW
MN1060 was used in Immunohistochemistry to demonstrate that cryo-EM allows atomic characterization of amyloid filaments from patient-derived material.
Thu Jul 13 00:00:00 EDT 2017
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Neuron
Fu H,Rodriguez GA,Herman M,Emrani S,Nahmani E,Barrett G,Figueroa HY,Goldberg E,Hussaini SA,Duff KE
MN1060 was used in immunohistochemistry - free floating to report the formation of mature tangles in Alzheimer's diseases is associated with excitatory cell loss and deficits in grid cell function
Wed Feb 08 00:00:00 EST 2017
Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.
Brain : a journal of neurology
Rodriguez-Rodriguez P,Sandebring-Matton A,Merino-Serrais P,Parrado-Fernandez C,Rabano A,Winblad B,Ávila J,Ferrer I,Cedazo-Minguez A
MN1060 was used in Immunohistochemistry-immunofluorescence to suggest that insulin retention in hyperphosphorylated tau-bearing neurons is a causative factor for the insulin resistance observed in tauopathies, and describe a novel neuropathological concept with important therapeutic implications.
Fri Dec 01 00:00:00 EST 2017
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Brain : a journal of neurology
Laurent C,Dorothée G,Hunot S,Martin E,Monnet Y,Duchamp M,Dong Y,Légeron FP,Leboucher A,Burnouf S,Faivre E,Carvalho K,Caillierez R,Zommer N,Demeyer D,Jouy N,Sazdovitch V,Schraen-Maschke S,Delarasse C,Buée L,Blum D
MN1060 was used in western blot to explore the role of hippocampal T cell infiltration in tau-driven pathophysiology and cognitive impairments
Sun Jan 01 00:00:00 EST 2017
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Brain : a journal of neurology
Halliday M,Radford H,Zents KAM,Molloy C,Moreno JA,Verity NC,Smith E,Ortori CA,Barrett DA,Bushell M,Mallucci GR
MN1060 was used in Western Blotting to identify two compounds, trazodone hydrochloride and dibenzoylmethane, which target eIF2-P-mediated translational repression, with applications in preventing neurodegeneration.
Thu Jun 01 00:00:00 EDT 2017
HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.
Molecular neurobiology
García-Ayllón MS,Botella-López A,Cuchillo-Ibañez I,Rábano A,Andreasen N,Blennow K,Ávila J,Sáez-Valero J
MN1060 was used in western blot to study the Alzheimer's disease brain for a decrease in HNK-1 carrier glycoproteins
Sun Jan 01 00:00:00 EST 2017
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nature communications
Zhang Z,Obianyo O,Dall E,Du Y,Fu H,Liu X,Kang SS,Song M,Yu SP,Cabrele C,Schubert M,Li X,Wang JZ,Brandstetter H,Ye K
MN1060 was used in immunohistochemistry and western blot to evaluate the efficacy of an orally bioactive and brain permeable gamma-secretase inhibitor in a mouse model of Alzheimer's disease
Mon Mar 27 00:00:00 EDT 2017
Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Herring A,Münster Y,Akkaya T,Moghaddam S,Deinsberger K,Meyer J,Zahel J,Sanchez-Mendoza E,Wang Y,Hermann DM,Arzberger T,Teuber-Hanselmann S,Keyvani K
MN1060 was used in western blot to study the attenuation of Alzheimer's pathology in mice due to kallikrein-8 inhibition
Thu Dec 01 00:00:00 EST 2016
Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology.
Brain : a journal of neurology
Ling H,Kovacs GG,Vonsattel JP,Davey K,Mok KY,Hardy J,Morris HR,Warner TT,Holton JL,Revesz T
MN1060 was used in immunohistochemistry to characterize preclinical subjects with corticobasal degeneration
Thu Dec 01 00:00:00 EST 2016
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
EMBO molecular medicine
Salta E,Sierksma A,Vanden Eynden E,De Strooper B
MN1060 was used in western blot to describe the role of miR-132 in amyloid and TAU pathology associated with Alzheimer's disease
Thu Sep 01 00:00:00 EDT 2016
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Autophagy
Pajares M,Jiménez-Moreno N,García-Yagüe ÁJ,Escoll M,de Ceballos ML,Van Leuven F,Rábano A,Yamamoto M,Rojo AI,Cuadrado A
MN1060 was used in immunohistochemistry - free floating and immunohistochemistry - paraffin section to identify NFE2L2/NRF2 as a regulator of autophagy gene expression and study its role in Alzheimer disease
Sun Oct 02 00:00:00 EDT 2016
Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia.
Brain pathology (Zurich, Switzerland)
Takeuchi R,Toyoshima Y,Tada M,Tanaka H,Shimizu H,Shiga A,Miura T,Aoki K,Aikawa A,Ishizawa S,Ikeuchi T,Nishizawa M,Kakita A,Takahashi H
MN1060 was used in immunohistochemistry - paraffin section to report a case of glial mixed tau and TDP-43 proteinopathies in a Japanese patient.
Fri Jan 01 00:00:00 EST 2016
The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments.
Neuropathology and applied neurobiology
Nishikawa T,Takahashi T,Nakamori M,Hosomi N,Maruyama H,Miyazaki Y,Izumi Y,Matsumoto M
MN1060 was used in immunohistochemistry - paraffin section to study the relationship between neurofibrillary tangles and raft domains
Thu Dec 01 00:00:00 EST 2016
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Neuropharmacology
Jiang T,Zhang YD,Chen Q,Gao Q,Zhu XC,Zhou JS,Shi JQ,Lu H,Tan L,Yu JT
MN1060 was used in western blot to elucidate modification microglial phenotype and neuroprotection in P301S tau transgenic mice via TREM2
Wed Jun 01 00:00:00 EDT 2016
Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Kasza Á,Hunya Á,Frank Z,Fülöp F,Török Z,Balogh G,Sántha M,Bálind Á,Bernáth S,Blundell KL,Prodromou C,Horváth I,Zeiler HJ,Hooper PL,Vigh L,Penke B
MN1060 was used in Immunohistochemistry to identify potent heat shock protein co-inducers that enhance protein homeostasis for the treatment of Alzheimer's disease, looking specifically at 1,4-dihydropyridine derivatives optimised for their ability to modulate cellular stress responses.
Sat May 07 00:00:00 EDT 2016
Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice.
Neuroscience letters
Elahi M,Motoi Y,Matsumoto SE,Hasan Z,Ishiguro K,Hattori N
MN1060 was used in western blot to test if short-term treadmill exercise changes tau modifications
Fri Jan 01 00:00:00 EST 2016
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Neurobiology of learning and memory
Van der Jeugd A,Vermaercke B,Halliday GM,Staufenbiel M,Götz J
MN1060 was used in immunohistochemistry - paraffin section to elucidate a mouse model of frontotemporal dementia by decreased social exploration, impulsivity, and executive dysfunction
Fri Apr 01 00:00:00 EDT 2016
Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies.
Frontiers in neuroscience
Pisa D,Alonso R,Rábano A,Carrasco L
MN1060 was used in immunohistochemistry - paraffin section to characterize specific antifungal antibodies that stain corpora amylacea of brain tissue from neurodegenerative diseases
Fri Mar 25 00:00:00 EDT 2016
Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex.
Aging
Koukouli F,Rooy M,Maskos U
MN1060 was used in immunohistochemistry to generate an adeno-associated viral vector expressing the human mutated amyloid precursor protein
Tue Dec 20 00:00:00 EST 2016
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Scientific reports
Gorsky MK,Burnouf S,Dols J,Mandelkow E,Partridge L
MN1060 was used in western blot to elucidate the exacerbation of human Tau neurotoxicity in vivo by acetylation mimic of lysine 280
Fri Mar 04 00:00:00 EST 2016
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Acta neuropathologica
Wagner J,Krauss S,Shi S,Ryazanov S,Steffen J,Miklitz C,Leonov A,Kleinknecht A,Göricke B,Weishaupt JH,Weckbecker D,Reiner AM,Zinth W,Levin J,Ehninger D,Remy S,Kretzschmar HA,Griesinger C,Giese A,Fuhrmann M
MN1060 was used in immunohistochemistry and western blot to report that the di-phenyl-pyrazole anle138b binds to and inhibits tau aggregation in vitro and in vivo
Sun Nov 01 00:00:00 EDT 2015
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Brain : a journal of neurology
Sepulveda-Diaz JE,Alavi Naini SM,Huynh MB,Ouidja MO,Yanicostas C,Chantepie S,Villares J,Lamari F,Jospin E,van Kuppevelt TH,Mensah-Nyagan AG,Raisman-Vozari R,Soussi-Yanicostas N,Papy-Garcia D
MN1060 was used in western blot to characterize Alzheimer's disease-related tau pathology by HS3ST2 expression in critical for the abonormal phosphorylation of tau
Fri May 01 00:00:00 EDT 2015
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo.
Neurobiology of disease
Violet M,Chauderlier A,Delattre L,Tardivel M,Chouala MS,Sultan A,Marciniak E,Humez S,Binder L,Kayed R,Lefebvre B,Bonnefoy E,Buée L,Galas MC
MN1060 was used in immunohistochemistry - paraffin section to determine the therapeutic window to prevent the formation of Tau aggregates
Thu Oct 01 00:00:00 EDT 2015
Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Miller N,Feng Z,Edens BM,Yang B,Shi H,Sze CC,Hong BT,Su SC,Cantu JA,Topczewski J,Crawford TO,Ko CP,Sumner CJ,Ma L,Ma YC
MN1060 was used in immunohistochemistry to determine if tau phosphorylation contributes to spinal muscular atrophy pathogenesis
Wed Apr 15 00:00:00 EDT 2015
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Journal of neurochemistry
Ittner A,Bertz J,Suh LS,Stevens CH,Götz J,Ittner LM
MN1060 was used in immunohistochemistry - paraffin section and western blot to determine the pathology in tau transgenic mice due to tau-targeting passive immunization
Thu Jan 01 00:00:00 EST 2015
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Journal of Alzheimer's disease : JAD
Dunn HC,Ager RR,Baglietto-Vargas D,Cheng D,Kitazawa M,Cribbs DH,Medeiros R
MN1060 was used in western blot to assess the effect of aging on brain lipoxin A4 levels using non-transgenic and 3xTg-AD mice.
Fri Aug 21 00:00:00 EDT 2015
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
Neuroscience
Li R,Xu DE,Ma T
MN1060 was used in western blot to elucidate the neuroprotective mechanism of statins
Thu May 21 00:00:00 EDT 2015
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Molecular neurodegeneration
Song L,Lu SX,Ouyang X,Melchor J,Lee J,Terracina G,Wang X,Hyde L,Hess JF,Parker EM,Zhang L
MN1060 was used in ELISA to use rTg4510 mice to elucidate pathogenesis of tau-induced disease.
Thu Mar 26 00:00:00 EDT 2015
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.
Cell death & disease
Mouton-Liger F,Rebillat AS,Gourmaud S,Paquet C,Leguen A,Dumurgier J,Bernadelli P,Taupin V,Pradier L,Rooney T,Hugon J
MN1060 was used in western blot to use a mouse thiamine deficiency model to assess the contribution of PKR in neuronal death.
Thu Jan 15 00:00:00 EST 2015
Different Brain Regions are Infected with Fungi in Alzheimer's Disease.
Scientific reports
Pisa D,Alonso R,Rábano A,Rodal I,Carrasco L
MN1060 was used in immunohistochemistry - paraffin section to study Alzheimer's disease and different brain regions infected with fungi
Thu Oct 15 00:00:00 EDT 2015
The domestic cat as a natural animal model of Alzheimer's disease.
Acta neuropathologica communications
Chambers JK,Tokuda T,Uchida K,Ishii R,Tatebe H,Takahashi E,Tomiyama T,Une Y,Nakayama H
MN1060 was used in immunohistochemistry - paraffin section to study Alzheimer's disease by use of a domestic cat animal model
Thu Dec 10 00:00:00 EST 2015
The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.
Frontiers in neuroscience
Brelstaff J,Ossola B,Neher JJ,Klingstedt T,Nilsson KP,Goedert M,Spillantini MG,Tolkovsky AM
MN1060 was used in immunocytochemistry to characterize live neurons cultured from adult P301S tau mice by use of the fluorescent pentameric oligothiophene pFTAA that identifies filamentous tau
Mon Jun 15 00:00:00 EDT 2015
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
The Journal of biological chemistry
Falcon B,Cavallini A,Angers R,Glover S,Murray TK,Barnham L,Jackson S,O'Neill MJ,Isaacs AM,Hutton ML,Szekeres PG,Goedert M,Bose S
MN1060 was used in immunocytochemistry to determine seeding potencies of recombinant and native Tau aggregates due to conformation
Fri Jan 09 00:00:00 EST 2015
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Neurobiology of disease
Baglietto-Vargas D,Kitazawa M,Le EJ,Estrada-Hernandez T,Rodriguez-Ortiz CJ,Medeiros R,Green KN,LaFerla FM
MN1060 was used in western blot to study the effect of endogenous murine tau on cognition and neurofibrillary tangles in a murine Alzheimer's disease model transgenically expressing human tau
Sat Feb 01 00:00:00 EST 2014
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Castillo-Carranza DL,Sengupta U,Guerrero-Muñoz MJ,Lasagna-Reeves CA,Gerson JE,Singh G,Estes DM,Barrett AD,Dineley KT,Jackson GR,Kayed R
MN1060 was used in immunohistochemistry and western blot to study the ability of an anti-oligomeric tau monoclonal antibody to specifically reduce oligomeric tau and improve memory and locomotion in a murine Alzheimer's disease model
Wed Mar 19 00:00:00 EDT 2014
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Forny-Germano L,Lyra e Silva NM,Batista AF,Brito-Moreira J,Gralle M,Boehnke SE,Coe BC,Lablans A,Marques SA,Martinez AM,Klein WL,Houzel JC,Ferreira ST,Munoz DP,De Felice FG
MN1060 was used in immunohistochemistry - free floating to study the impact of amyloid-beta oligomers in the brains of rats and adult cynomolgus macaques
Wed Oct 08 00:00:00 EDT 2014
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Stancu IC,Ris L,Vasconcelos B,Marinangeli C,Goeminne L,Laporte V,Haylani LE,Couturier J,Schakman O,Gailly P,Pierrot N,Kienlen-Campard P,Octave JN,Dewachter I
MN1060 was used in immunohistochemistry (free floating) to present data that suggests that pathological Aβ species induce changes in Tau that contribute to cognitive deficits correlating with synaptic deficits and hippocampal atrophy in an Alzheimer's disease model.
Sun Jun 01 00:00:00 EDT 2014
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
The American journal of pathology
Abbondante S,Baglietto-Vargas D,Rodriguez-Ortiz CJ,Estrada-Hernandez T,Medeiros R,Laferla FM
MN1060 was used in western blot to study the cognitive defects observed in type 1 diabetes and the role of tau in mediating these effects
Sat Mar 01 00:00:00 EST 2014
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Frontiers in aging neuroscience
Castro-Alvarez JF,Uribe-Arias SA,Kosik KS,Cardona-Gómez GP
MN1060 was used in western blot to use triple transgenic Alzhemier's mice to study short- and long-term CDK5 knockdown and prevention of spatial memory dysfunction and tau pathology
Mon Oct 13 00:00:00 EDT 2014
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Experimental neurology
Yamada ES,Respondek G,Müssner S,de Andrade A,Höllerhage M,Depienne C,Rastetter A,Tarze A,Friguet B,Salama M,Champy P,Oertel WH,Höglinger GU
MN1060 was used in immunohistochemistry to study the increased tau phosphorylation following treatment with a mitochondrial complex I inhibitor in a tau transgenic mouse model
Sat Mar 01 00:00:00 EST 2014
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Neuropharmacology
Jiang T,Yu JT,Zhu XC,Zhang QQ,Cao L,Wang HF,Tan MS,Gao Q,Qin H,Zhang YD,Tan L
MN1060 was used in western blot to study the ability of the rapamycin analog temsirolimus to promote autophagic clearance of hyperphosphorylated tau and improve memory deficits in animal models
Wed Oct 01 00:00:00 EDT 2014
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
FEBS letters
Inoue H,Hiradate Y,Shirakata Y,Kanai K,Kosaka K,Gotoh A,Fukuda Y,Nakai Y,Uchida T,Sato E,Tanemura K
MN1060 was used in immunohistochemistry to study the role of Tau phosphorylation in murine spermatogenesis during meiosis
Thu May 29 00:00:00 EDT 2014
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Molecular neurodegeneration
Ohia-Nwoko O,Montazari S,Lau YS,Eriksen JL
MN1060 was used in immunohistochemistry - paraffin section and western blot to evaluate motor function and tau pathology of P301S tau transgenic mice
Fri Nov 28 00:00:00 EST 2014
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.
Acta neuropathologica communications
Dujardin S,Lécolle K,Caillierez R,Bégard S,Zommer N,Lachaud C,Carrier S,Dufour N,Aurégan G,Winderickx J,Hantraye P,Déglon N,Colin M,Buée L
MN1060 was used in immunohistochemistry to discuss the molecular and cellular mechanisms that contribute to disease progression in sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy
Thu Jan 30 00:00:00 EST 2014
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
PloS one
Petry FR,Pelletier J,Bretteville A,Morin F,Calon F,Hébert SS,Whittington RA,Planel E
MN1060 was used in Western Blotting to characterise the profiles of commonly used anti-tau antibodies in four different mouse models, suggesting that a high risk of artefactual signal exists.
Mon Dec 22 00:00:00 EST 2014
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Vaccines
Richter M,Mewes A,Fritsch M,Krügel U,Hoffmann R,Singer D
MN1060 was used in western blot to study protection of transgenic P301S mice against tau aggregation in Alzheimer's disease by doubly phosphorylated peptied vaccines
Tue Jul 29 00:00:00 EDT 2014
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
Acta neuropathologica
Wu TH,Lu YN,Chuang CL,Wu CL,Chiang AS,Krantz DE,Chang HY
MN1060 was used in immunocytochemistry to report that expression of human wild-type tau is sufficient to disrupt the survival of dopaminergic neurons in a Drosophila model
Wed May 01 00:00:00 EDT 2013
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Acta neuropathologica
Clippinger AK,D'Alton S,Lin WL,Gendron TF,Howard J,Borchelt DR,Cannon A,Carlomagno Y,Chakrabarty P,Cook C,Golde TE,Levites Y,Ranum L,Schultheis PJ,Xu G,Petrucelli L,Sahara N,Dickson DW,Giasson B,Lewis J
MN1060 was used in immunohistochemistry - paraffin section to test if a primary proteinopathy might secondarily drive TDP-43 proteinopathy
Mon Jul 01 00:00:00 EDT 2013
Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
Molecular therapy : the journal of the American Society of Gene Therapy
Caillierez R,Bégard S,Lécolle K,Deramecourt V,Zommer N,Dujardin S,Loyens A,Dufour N,Aurégan G,Winderickx J,Hantraye P,Déglon N,Buée L,Colin M
MN1060 was used in immunohistochemistry and western blot to study the slow and progressive neurodegeneration induced in rat brain by lentiviral-mediated transduction with wild-type human tau
Mon Jul 01 00:00:00 EDT 2013
NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.
Aging cell
Burnouf S,Martire A,Derisbourg M,Laurent C,Belarbi K,Leboucher A,Fernandez-Gomez FJ,Troquier L,Eddarkaoui S,Grosjean ME,Demeyer D,Muhr-Tailleux A,Buisson A,Sergeant N,Hamdane M,Humez S,Popoli P,Buée L,Blum D
MN1060 was used in immunohistochemistry to study the role of impaired NMDA receptor function in the blunted effect of BDNF on synaptic enhancement in a model of tau pathology
Fri Feb 01 00:00:00 EST 2013
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Diabetes
Leboucher A,Laurent C,Fernandez-Gomez FJ,Burnouf S,Troquier L,Eddarkaoui S,Demeyer D,Caillierez R,Zommer N,Vallez E,Bantubungi K,Breton C,Pigny P,Buée-Scherrer V,Staels B,Hamdane M,Tailleux A,Buée L,Blum D
MN1060 was used in western blot to study the effects of diet-induced obesity on tau pathology
Wed May 01 00:00:00 EDT 2013
Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Lahmy V,Meunier J,Malmström S,Naert G,Givalois L,Kim SH,Villard V,Vamvakides A,Maurice T
MN1060 was used in Western Blotting to establish whether the mixed σ1/muscarinic ligand ANAVEX2-73 could have the ability to reduce the appearance of hyperphosphorylated Tau and amyloid-β1-42.
Thu Aug 01 00:00:00 EDT 2013
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
ACS chemical neuroscience
Alonso E,Vale C,Vieytes MR,Botana LM
MN1060 was used in western blot to study the role of PKC activation in the mechanism underyling the beneficial effects of yessotoxin on tau and Abeta pathology in a cellular model of Alzheimer's disease
Wed Jul 17 00:00:00 EDT 2013
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Neurobiology of aging
Cancino GI,Miller FD,Kaplan DR
MN1060 was used in western blot to study the effects of p73 haploinsufficiency on tau phosphorylation status and the activity of GSK3-beta, c-Abl and Cdk5 in murine models of ageing and Alzheimer's disease
Fri Feb 01 00:00:00 EST 2013
Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies.
Chembiochem : a European journal of chemical biology
Klingstedt T,Blechschmidt C,Nogalska A,Prokop S,Häggqvist B,Danielsson O,Engel WK,Askanas V,Heppner FL,Nilsson KP
MN1060 was used in immunohistochemistry to develop novel luminescent congugated thiophenes for use as amyloid ligands to detect disease-associated protein inclusion bodies
Mon Mar 18 00:00:00 EDT 2013
Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.
PloS one
Garringer HJ,Murrell J,Sammeta N,Gnezda A,Ghetti B,Vidal R
MN1060 was used in immunohistochemistry to study the effect of transgenic expression of a dementia-causing BRI2 mutant on tau metabolism and synaptophysin expression
Tue Aug 27 00:00:00 EDT 2013
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Acta neuropathologica communications
Hoffmann NA,Dorostkar MM,Blumenstock S,Goedert M,Herms J
MN1060 was used in immunohistochemistry to study the potential involvement of pre-fibrilliary tau in the defective plasticity of cortical dendritic spines observed in transgenic mice bearing the P301S tau mutation
Tue Dec 17 00:00:00 EST 2013
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
PloS one
Ozcelik S,Fraser G,Castets P,Schaeffer V,Skachokova Z,Breu K,Clavaguera F,Sinnreich M,Kappos L,Goedert M,Tolnay M,Winkler DT
MN1060 was used in immunohistochemistry and western blot to study the protective effects of rapamycin against tau pathology in a murine transgenic model
Mon Dec 09 00:00:00 EST 2013
PINCH in the cellular stress response to tau-hyperphosphorylation.
PloS one
Ozdemir AY,Rom I,Kovalevich J,Yen W,Adiga R,Dave RS,Langford D
MN1060 was used in western blot to study the ability of PINCH in bind and stabilize hyperphoshorylated tau
Mon Sep 30 00:00:00 EDT 2013
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
Acta neuropathologica
Collins M,Riascos D,Kovalik T,An J,Krupa K,Krupa K,Hood BL,Conrads TP,Renton AE,Traynor BJ,Bowser R
MN1060 was used in immunohistochemistry to study the role of the RNA-binding motif 45 protein in the inclusion body pathology of ALS, FTLD-TDP and Alzheimer's patients
Thu Nov 01 00:00:00 EDT 2012
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
The Journal of pathology
Nijholt DA,van Haastert ES,Rozemuller AJ,Scheper W,Hoozemans JJ
MN1060 was used in immunohistochemistry to investigate the unfolded protein response in the hippocampus of tauopathies.
Sun Apr 01 00:00:00 EDT 2012
The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Vidal R,Sammeta N,Garringer HJ,Sambamurti K,Miravalle L,Lamb BT,Ghetti B
MN1060 was used in immunohistochemistry to study the effect of transgenic expression of a mutant presenilin on amyloid deposition in mice expressing human APP
Sun Jul 01 00:00:00 EDT 2012
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Neurotoxicology
Rahman A,Khan KM,Al-Khaledi G,Khan I,Al-Shemary T
MN1060 was used in western blot to study the role of hippocampal PP1 and PP2A activation in the deleterious effects of lead on learning and memory in a rat model
Fri Jun 01 00:00:00 EDT 2012
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S.
Journal of Alzheimer's disease : JAD
Deramecourt V,Lebert F,Maurage CA,Fernandez-Gomez FJ,Dujardin S,Colin M,Sergeant N,Buée-Scherrer V,Clot F,Ber IL,Brice A,Pasquier F,Buée L
MN1060 was used in immunohistochemistry to study the clinical and molecular characteristics of a novel P332S tau mutation
Mon Jul 08 00:00:00 EDT 2013
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Current Alzheimer research
Troquier L,Caillierez R,Burnouf S,Fernandez-Gomez FJ,Grosjean ME,Zommer N,Sergeant N,Schraen-Maschke S,Blum D,Buee L
MN1060 was used in immunohistochemistry to study the therapeutic efficacy of active immunization with a phospho-serine 422 Tau peptide in a murine transgenic Tau model
Tue May 01 00:00:00 EDT 2012
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Experimental brain research
Fine JM,Baillargeon AM,Renner DB,Hoerster NS,Tokarev J,Colton S,Pelleg A,Andrews A,Sparley KA,Krogh KM,Frey WH,Hanson LR
MN1060 was used in western blot to study the molecular and behavioural effects of deferoxamine in tau transgenic mice
Fri Jun 01 00:00:00 EDT 2012
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Acta biologica Hungarica
Rahman A,Khan KM,Al-Khaledi G,Khan I,Attur S
MN1060 was used in western blot to study tau phosphorylation in response to early post-natal exposure to lead
Sat Dec 01 00:00:00 EST 2012
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Molecular neurodegeneration
Inoue K,Rispoli J,Kaphzan H,Klann E,Chen EI,Kim J,Komatsu M,Abeliovich A
MN1060 was used in immunohistochemistry to study the role of the phospho-Tau pathway in the mechanism by which deficient macroautophagy promotes age-related neurodegeneration
Fri Sep 21 00:00:00 EDT 2012
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
PloS one
Kawakami F,Yabata T,Ohta E,Maekawa T,Shimada N,Suzuki M,Maruyama H,Ichikawa T,Obata F
MN1060 was used in western blot to investigate the important roles of LRRK2 in phosphorylation-mediated dissociation of tau from microtubules
Mon Jun 11 00:00:00 EDT 2012
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
The Journal of biological chemistry
Mondragón-Rodríguez S,Trillaud-Doppia E,Dudilot A,Bourgeois C,Lauzon M,Leclerc N,Boehm J
MN1060 was used in immunocytochemistry to study the role of NMDA receptor-dependent tau phosphorylation in modulating the interaction of endogenous tau with synaptic proteins
Fri Sep 14 00:00:00 EDT 2012
Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats.
PloS one
Chambers JK,Uchida K,Harada T,Tsuboi M,Sato M,Kubo M,Kawaguchi H,Miyoshi N,Tsujimoto H,Nakayama H
MN1060 was used in immunohistochemistry - paraffin section to identify and characterize Abeta deposits in the brains of Japanese Tsushima leopard cats
Tue Jun 11 00:00:00 EDT 2013
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Scientific reports
Bretteville A,Marcouiller F,Julien C,El Khoury NB,Petry FR,Poitras I,Mouginot D,Lévesque G,Hébert SS,Planel E
MN1060 was used in western blot to test if hypothermia could be used to assess tau kinase inhibitors efficacy
Sun Mar 17 00:00:00 EDT 2013
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Neurobiology of disease
Belarbi K,Burnouf S,Fernandez-Gomez FJ,Laurent C,Lestavel S,Figeac M,Sultan A,Troquier L,Leboucher A,Caillierez R,Grosjean ME,Demeyer D,Obriot H,Brion I,Barbot B,Galas MC,Staels B,Humez S,Sergeant N,Schraen-Maschke S,Muhr-Tailleux A,Hamdane M,Buée L,Blum D
MN1060 was used in immunohistochemistry to investigate the influence of long-term voluntary exercise on a transgenic mouse model of Tau pathology
Mon Aug 01 00:00:00 EDT 2011
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tran HT,LaFerla FM,Holtzman DM,Brody DL
MN1060 was used in western blot to investigate the effect of traumatic brain injury on the development of Alzheimer disease pathology
Wed Jun 29 00:00:00 EDT 2011
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Human molecular genetics
Kudo LC,Parfenova L,Ren G,Vi N,Hui M,Ma Z,Lau K,Gray M,Bardag-Gorce F,Wiedau-Pazos M,Hui KS,Karsten SL
MN1060 was used in immunohistochemistry to investigate the effect of puromycin-sensitive aminopeptidase on the neuropathology in a transgenic Alzheimer disease mice model
Sun May 01 00:00:00 EDT 2011
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Neurochemistry international
Alonso E,Vale C,Vieytes MR,Laferla FM,Giménez-Llort L,Botana LM
MN1060 was used in western blot to investigate the effect of 13-desmethyl spirolide-C on both tau and beta-amyloid peptide
Thu Dec 01 00:00:00 EST 2011
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Neuroscience letters
Koike MA,Garcia FG,Kitazawa M,Green KN,Laferla FM
MN1060 was used in western blot to investigate the phosphorylation and aggregation of tau protein in the 3xTg-AD mice
Mon May 09 00:00:00 EDT 2011
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.
The Journal of biological chemistry
Emmer KL,Waxman EA,Covy JP,Giasson BI
MN1060 was used in immunohistochemistry to investigate the role of alpha-syn in the development of neurodegenerative diseases
Fri Oct 07 00:00:00 EDT 2011
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Journal of neuroinflammation
Fonseca MI,Chu SH,Berci AM,Benoit ME,Peters DG,Kimura Y,Tenner AJ
MN1060 was used in immunohistochemistry to investigate the role of complement activation pathways in Alzheimer disease
Sat Jan 15 00:00:00 EST 2011
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
PloS one
Ohmi K,Zhao HZ,Neufeld EF
MN1060 was used in immunohistochemistry to study defects in the medial entorhinal cortex and dentate gyrus in a mouse model of Sanfilippo syndrome type B
Tue Apr 10 00:00:00 EDT 2012
Axonal inclusions in spinocerebellar ataxia type 3.
Acta neuropathologica
Seidel K,den Dunnen WF,Schultz C,Paulson H,Frank S,de Vos RA,Brunt ER,Deller T,Kampinga HH,Rüb U
MN1060 was used in immunohistochemistry to investigate the protein accumulation in neurons of SCA3 patients
Fri Oct 01 00:00:00 EDT 2010
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
The American journal of pathology
Koike MA,Green KN,Blurton-Jones M,Laferla FM
MN1060 was used in western blot to investigate the effect of oligemic hypoperfusion on tau and amyloid-beta in 3xTg-Alzheimer disease mice
Thu Jul 01 00:00:00 EDT 2010
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
Journal of neurochemistry
Bertrand J,Sénéchal P,Zummo-Soucy M,Plouffe V,Leclerc N
MN1060 was used in immunocytochemistry to investigate the effect of tau dephosphorylation on abolishing its pathological epitopes
Wed Sep 01 00:00:00 EDT 2010
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
Acta neuropathologica
Nogalska A,Terracciano C,D'Agostino C,King Engel W,Askanas V
MN1060 was used in immunocytochemistry to investigate the distribution of p62 in sporadic inclusion-body myositis muscle fibers and its application as a biomarker
Tue Sep 01 00:00:00 EDT 2009
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Proceedings of the National Academy of Sciences of the United States of America
Ohmi K,Kudo LC,Ryazantsev S,Zhao HZ,Karsten SL,Neufeld EF
MN1060 was used in immunohistochemistry to investigate the dysregulation of gene expression and tau phosphorylation in MPS III B mice
Tue May 19 00:00:00 EDT 2009
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Neurobiology of aging
Wiedau-Pazos M,Wong E,Solomon E,Alarcon M,Geschwind DH
MN1060 was used in immunohistochemistry and western blot to suggest Wnt-activation occurs prior to 3 months of age in the JNPL3 mouse model of frontotemporal dementia
Thu Jan 01 00:00:00 EST 2009
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Human molecular genetics
Chatterjee S,Sang TK,Lawless GM,Jackson GR
MN1060 was used in western blot to study the roles of GSK3 beta, MARK and Cdk5 in the relationship between tau toxicity and phosphorylation
Thu Jan 01 00:00:00 EST 2009
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
Journal of Alzheimer's disease : JAD
Capsoni S,Covaceuszach S,Ugolini G,Spirito F,Vignone D,Stefanini B,Amato G,Cattaneo A
MN1060 was used in immunohistochemistry to evaluate intranasal and ocular nerve growth factor administration in mice
Wed Jun 17 00:00:00 EDT 2009
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
Journal of neural transmission (Vienna, Austria : 1996)
van Eersel J,Bi M,Ke YD,Hodges JR,Xuereb JH,Gregory GC,Halliday GM,Götz J,Kril JJ,Ittner LM
MN1060 was used in western blot to study the differences in soluble tau phpsphorylation and tau kinase activity in Pick's disease as compared to Alzheimer's disease
Thu Oct 01 00:00:00 EDT 2009
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
The Journal of biological chemistry
Ittner LM,Ke YD,Götz J
MN1060 was used in western blot to study the interaction between phosphorylated Tau and c-Jun N-terminal kinase-interacting protein 1 in Alzheimer disease
Fri Jul 31 00:00:00 EDT 2009
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
PloS one
Rahman A,Ting K,Cullen KM,Braidy N,Brew BJ,Guillemin GJ
MN1060 was used in western blot to study the effect of quinolinic acid on tau phosphorylation in neurons
Wed Jul 22 00:00:00 EDT 2009
Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes.
The American journal of pathology
Fein JA,Sokolow S,Miller CA,Vinters HV,Yang F,Cole GM,Gylys KH
MN1060 was used in immunocytochemistry to study the co-localization of beta amyloid and phosphorylated tau in Alzhiemer's disease synaptosomes and the significance for the amyloid cascade model
Sun Jun 01 00:00:00 EDT 2008
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Cell cycle (Georgetown, Tex.)
Rossi G,Dalprà L,Crosti F,Lissoni S,Sciacca FL,Catania M,Di Fede G,Mangieri M,Giaccone G,Croci D,Tagliavini F
MN1060 was used in immunocytochemistry to study a potential role of tau in chromosome stability via its interaction with chromatin and microtubules
Sun Jun 15 00:00:00 EDT 2008
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Proceedings of the National Academy of Sciences of the United States of America
Luo W,Dou F,Rodina A,Chip S,Kim J,Zhao Q,Moulick K,Aguirre J,Wu N,Greengard P,Chiosis G
MN1060 was used in western blot to study the contribution of heat-shock protein 90 towards tauopathies
Tue May 29 00:00:00 EDT 2007
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Green KN,Martinez-Coria H,Khashwji H,Hall EB,Yurko-Mauro KA,Ellis L,LaFerla FM
MN1060 was used in western blot to study the effect of docosahexaenoic acid and docosapentaenoic acid on amyloid beta and tau pathology
Wed Apr 18 00:00:00 EDT 2007
Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.
Molecular biology of the cell
Steinhilb ML,Dias-Santagata D,Fulga TA,Felch DL,Feany MB
MN1060 was used in western blot to study the mechanism for the neurodegeneration promoted by tau phosphorylation
Sat Dec 01 00:00:00 EST 2007
Cell type-specific processing of human Tau proteins in Drosophila.
FEBS letters
Grammenoudi S,Kosmidis S,Skoulakis EM
MN1060 was used in western blot to show that the differential phosphorylation and stability of Tau is cell-specific using transgenic mice
Mon Aug 21 00:00:00 EDT 2006
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
The American journal of pathology
Klein RL,Lin WL,Dickson DW,Lewis J,Hutton M,Duff K,Meyer EM,King MA
MN1060 was used in Immunohistochemistry to show that tau gene transfer to the hippocampal region of amyloid-depositing transgenic mice produced pretangles and threads, as well as intensely tau-immunoreactive neurites in amyloid plaques.
Thu Jan 01 00:00:00 EST 2004
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
The American journal of pathology
Klein RL,Lin WL,Dickson DW,Lewis J,Hutton M,Duff K,Meyer EM,King MA
MN1060 was used in Immunohistochemistry to show that tau gene transfer to the hippocampal region of amyloid-depositing transgenic mice produced pretangles and threads, as well as intensely tau-immunoreactive neurites in amyloid plaques.
Thu Jan 01 00:00:00 EST 2004
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.
Journal of neurochemistry
Sahara N,Lewis J,DeTure M,McGowan E,Dickson DW,Hutton M,Yen SH
MN1060 was used in western blot to study the mechanism for tau protein assembly
Sun Dec 01 00:00:00 EST 2002
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Biochemistry
Yoshida H,Goedert M
MN1060 was used in western blot to investigate the function of chicken brain tau
Tue Dec 24 00:00:00 EST 2002
