Invitrogen

Phospho-VANGL2 (Ser14, Ser17) Recombinant Rabbit Monoclonal Antibody (4C7Y1)

Phospho-VANGL2 (Ser14, Ser17) Antibody in Western Blot (WB)

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Phospho-VANGL2 (Ser14, Ser17) Antibody (MA5-42957) in WB

Western blot analysis of Phospho-VANGL2 (Ser14, Ser17) in C6 cells. Samples were incubated with Phospho-VANGL2 (Ser14, Ser17) Monoclonal antibody (Product # MA5-42957) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. C6 cells were treated by wnt (100 ng/mL) for 30 minutes. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry mi... View More

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产品信息

MA5-42957

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

4C7Y1

抗原

A phospho specific peptide corresponding to residues surrounding S14/S17 of human VANGL2

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2912098

产品详细信息

Positive test controls include: HeLa. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.

靶标信息

Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Loop-tail protein 1 homolog; loop-tail-associated protein; MGC119403; MGC119404; Strabismus 1; Van Gogh-like protein 2; vang; vang-like 2 (van gogh, Drosophila); Vang-like protein 2

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基因别名: KIAA1215; LPP1; LTAP; STB1; STBM; STBM1; VANGL2

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UniProt ID: (Human) Q9ULK5

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Entrez Gene ID: (Human) 57216

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功能

protein binding

参与通路