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产品信息
PA5-64729
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human VHL (Phospho-Ser68)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2662841
产品详细信息
Phospho-VHL (Ser68) Polyclonal Antibody detects endogenous levels of VHL only when phosphorylated at Ser68.
靶标信息
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: elongin binding protein; Protein G7; pVHL; VHL19; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
基因别名: HRCA1; pVHL; RCA1; VHL; VHL1; Vhlh
UniProt ID: (Human) P40337, (Mouse) P40338, (Rat) Q64259
Entrez Gene ID: (Human) 7428, (Mouse) 22346, (Rat) 24874
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
regulation of transcription, DNA-templated
proteolysis
negative regulation of cell proliferation
protein ubiquitination
negative regulation of apoptotic process
positive regulation of cell differentiation
positive regulation of transcription, DNA-templated
protein stabilization
regulation of transcription from RNA polymerase II promoter in response to hypoxia
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
angiogenesis
response to hypoxia
type B pancreatic cell differentiation
pancreatic A cell differentiation
NLS-bearing protein import into nucleus
proteasomal protein catabolic process
protein transport
protein catabolic process
neuron differentiation
extracellular matrix organization
regulation of catecholamine metabolic process
blood vessel endothelial cell migration
negative regulation of endothelial cell differentiation
protein heterooligomerization
regulation of thymocyte apoptotic process
negative regulation of thymocyte apoptotic process
negative regulation of hypoxia-inducible factor-1alpha signaling pathway
regulation of apoptotic signaling pathway
response to ethanol
