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This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
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Immunogen sequence: SASEP
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: C-RAF; C-Raf proto-oncogene, serine/threonine kinase; cRaf; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; Proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; vraf1 murine le
基因别名: c-Raf; CMD1NN; CRAF; NS5; RAF; Raf-1; RAF1
UniProt ID: (Human) P04049, (Rat) P11345
Entrez Gene ID: (Human) 5894, (Rat) 24703