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Phospho-gp130 (Ser782) Antibody (BS-10122R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded human cervical cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with phospho-gp130 (Ser782) Polyclonal Antibody, Unconjugated (bs-10122R) at 1:400 overnight at 4°C, followed by a conjugated sec... View More
产品信息
BS-10122R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic phosphopeptide derived from human gp130 around the phosphorylation site of Ser782.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; Oncostatin-M receptor subunit alpha
基因别名: 5133400A03Rik; AA389424; Ac1055; BB405851; CD130; CDW130; D13Ertd699e; GP130; IL-6RB; IL6ST
UniProt ID: (Human) P40189, (Mouse) Q00560
Entrez Gene ID: (Human) 3572, (Rat) 25205, (Mouse) 16195
ciliary neurotrophic factor receptor activity
interleukin-6 receptor activity
interleukin-11 receptor activity
leukemia inhibitory factor receptor activity
oncostatin-M receptor activity
ciliary neurotrophic factor receptor binding
interleukin-6 receptor binding
protein binding
growth factor binding
interleukin-11 binding
interleukin-6 binding
protein homodimerization activity
interleukin-27 receptor activity
protein heterodimerization activity
cytokine receptor activity
transmembrane signal receptor
positive regulation of acute inflammatory response
positive regulation of adaptive immune response
glycogen metabolic process
positive regulation of cell proliferation
regulation of Notch signaling pathway
positive regulation of vascular endothelial growth factor production
positive regulation of cardiac muscle hypertrophy
viral process
cytokine-mediated signaling pathway
response to cytokine
interleukin-11-mediated signaling pathway
oncostatin-M-mediated signaling pathway
positive regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of apoptotic process
positive regulation of osteoblast differentiation
positive regulation of astrocyte differentiation
leukemia inhibitory factor signaling pathway
interleukin-6-mediated signaling pathway
interleukin-27-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
triglyceride mobilization
signal transduction
response to nutrient
positive regulation of smooth muscle cell migration
regulation of hormone secretion
negative regulation of cytosolic calcium ion concentration
negative regulation of interleukin-6-mediated signaling pathway
