Invitrogen

Phospho-hnRNP K (Ser216) Polyclonal Antibody

查看其他24个hnRNP K抗体

产品信息

PA5-40174

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide sequence around phosphorylation site of serine 216 (S-E-S(p)-P-I) derived from Human hnRNP K.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2608383

产品详细信息

This antibody is predicted to react with mouse and rat based on sequence homology.

靶标信息

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CSBP; dC stretch-binding protein; dC-stretch binding protein; FLJ41122; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; RP11-575L7.1; Transformation up-regulated nuclear protein; transformation upregulated nuclear protein; TUNP

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基因别名: AUKS; CSBP; HNRNPK; HNRPK; KBBP; NOVA; TUNP

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UniProt ID: (Human) P61978, (Rat) P61980, (Mouse) P61979

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Entrez Gene ID: (Human) 3190, (Rat) 117282, (Mouse) 15387

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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding single-stranded DNA binding RNA binding mRNA 3'-UTR binding protein binding lamin binding transcription factor binding protein domain specific binding pre-mRNA 3'-splice site binding heat shock protein binding actinin binding ribonucleoprotein complex binding poly(A) RNA binding ATPase binding cadherin binding involved in cell-cell adhesion mRNA CDS binding C-rich single-stranded DNA binding core promoter proximal region DNA binding nucleic acid binding DNA binding RNA metabolism protein

参与通路

negative regulation of transcription from RNA polymerase II promoter mRNA splicing, via spliceosome ovarian follicle development kidney development liver development transcription from RNA polymerase II promoter RNA processing acute-phase response signal transduction peripheral nervous system development aging gene expression regulation of low-density lipoprotein particle clearance response to activity viral process protein sumoylation cerebellum development hippocampus development cerebral cortex development lung development negative regulation of protein binding cellular response to insulin stimulus positive regulation of RNA splicing camera-type eye development negative regulation of apoptotic process positive regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of transcription from RNA polymerase II promoter negative regulation of mRNA splicing, via spliceosome positive regulation of receptor-mediated endocytosis thymus development positive regulation of synaptic transmission positive regulation of dendritic spine development cellular response to amino acid stimulus cellular response to glucose stimulus regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter cellular response to rapamycin positive regulation of synapse maturation cell-cell adhesion positive regulation of long-term synaptic potentiation response to salt regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of dendrite extension cellular response to forskolin positive regulation of protein localization to cell surface negative regulation of branching morphogenesis of a nerve transcription, DNA-templated regulation of transcription, DNA-templated mRNA processing RNA splicing regulation of transcription from RNA polymerase II promoter positive regulation of neuron projection development cellular response to organic cyclic compound