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Phospho-mu-Opioid Receptor (Thr379) Antibody (7TM0319E-IC) in IHC (PFA)
Immunohistochemical identification of Agonist-induced Threonine379 phosphorylation of the mu -Opioid Receptor in mouse spinal cord. Mice were either injected subcutaneously with saline or fentanyl citrate (0, 3 mg/kg bodyweight) for 15 min. Animals were then transcardially perfused, fixed and stained in presence of phosphatase and protease inhibitors. Shown are confocal images of coronal sections of the spi... View More
产品信息
7TM0319E-IC
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human MOP around the phosphorylation site of Thr379.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hMOP; KIAA0403; M-OR-1; MOP; MOP receptor; MOR-1; MOR-1C; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant mMOR-1Z; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; Mu-type opioid receptor; MUOR1; Opioid mu receptor; Opioid Receptor; Opioid receptor B; opioid receptor, mu 1; OTTHUMP00000017463
基因别名: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; MORA; muOR; OPRM; OPRM1; Oprrm1; Ror-b
UniProt ID: (Human) P35372, (Rat) Q64120, (Mouse) P42866
Entrez Gene ID: (Human) 4988, (Rat) 25601, (Mouse) 18390
G-protein alpha-subunit binding
G-protein coupled receptor activity
beta-endorphin receptor activity
voltage-gated calcium channel activity
protein binding
protein C-terminus binding
protein domain specific binding
filamin binding
G-protein beta-subunit binding
morphine receptor activity
neuropeptide binding
opioid receptor activity
signal transducer activity
G-protein coupled receptor
transmembrane signal receptor
acute inflammatory response to antigenic stimulus
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating dopamine receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
sensory perception
locomotory behavior
negative regulation of cell proliferation
response to radiation
sensory perception of pain
adenylate cyclase-inhibiting opioid receptor signaling pathway
response to food
positive regulation of appetite
response to lipopolysaccharide
cellular response to stress
wound healing
response to cocaine
eating behavior
estrous cycle
behavioral response to ethanol
positive regulation of neurogenesis
regulation of sensory perception of pain
excitatory postsynaptic potential
negative regulation of Wnt protein secretion
positive regulation of ERK1 and ERK2 cascade
calcium ion transmembrane transport
response to growth factor
cellular response to morphine
regulation of N-methyl-D-aspartate selective glutamate receptor activity
immune response
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
opioid receptor signaling pathway
response to morphine
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
negative regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
negative regulation of cytosolic calcium ion concentration
signal transduction
negative regulation of cAMP biosynthetic process
