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Polycystin 1 Antibody (PA5-115779) in IHC (P)
Immunohistochemistry analysis of PKD1 in human kidney cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115779) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115779
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PKD1(Accession P98161), corresponding to amino acid residues Y2444-E2494.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900414
产品详细信息
Antibody detects endogenous levels of total Polycystin 1.
靶标信息
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Autosomal dominant polycystic kidney disease 1 protein; Autosomal dominant polycystic kidney disease 1 protein homolog; PC1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease 1 homolog; polycystin-1; polycystic kidney disease-associated protein; polycystin 1; Polycystin-1; transient receptor potential cation channel, subfamily P, member 1
基因别名: mFLJ00285; PBP; Pc-1; PC1; PKD1; TRPP1
UniProt ID: (Human) P98161, (Mouse) O08852
Entrez Gene ID: (Human) 5310, (Rat) 24650, (Mouse) 18763
cartilage condensation
in utero embryonic development
kidney development
liver development
embryonic placenta development
protein export from nucleus
nitrogen compound metabolic process
cell cycle arrest
homophilic cell adhesion via plasma membrane adhesion molecules
cell-matrix adhesion
calcium-independent cell-matrix adhesion
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
heart development
anatomical structure morphogenesis
single organismal cell-cell adhesion
peptidyl-serine phosphorylation
spinal cord development
neural tube development
establishment of cell polarity
regulation of cell adhesion
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
positive regulation of protein binding
response to fluid shear stress
lymph vessel morphogenesis
cytoplasmic sequestering of transcription factor
skin development
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
branching morphogenesis of an epithelial tube
genitalia development
detection of mechanical stimulus
cartilage development
regulation of mitotic spindle organization
lung epithelium development
placenta blood vessel development
regulation of proteasomal protein catabolic process
calcium ion transmembrane transport
mesonephric tubule development
mesonephric duct development
metanephric collecting duct development
metanephric ascending thin limb development
metanephric proximal tubule development
metanephric distal tubule morphogenesis
blood vessel development
calcium ion transport
renal system development
cation transmembrane transport
patterning of lymph vessels
