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PrP Antibody (PA1-41673) in WB
Western blot analysis of PrP in recombinant fusion protein. Samples were incubated in PrP polyclonal antibody (Product # PA1-41673 using a dilution of 5 µg/mL. (A) recombinant fusion protein containing amino acids 217-229 and (B) fusion partner without these amino acids.
产品信息
PA1-41673
产品规格
种属反应
Bovine,
Sheep
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 217-229 of BSE.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 0.2% gelatin
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2237759
产品详细信息
Suggested positive control: recombinant fusion protein.
靶标信息
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alternative prion protein; AltPrP; BSE; CD230; Major prion protein; Major scrapie-associated fibril protein 1; MGC26679; PK resistant core; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; PrP; PrPc; TSE
基因别名: AltPrP; prn; PRNP; PRP; PRPC; SIP
UniProt ID: (Bovine) F7VJQ2, (Sheep) P23907
Entrez Gene ID: (Bovine) 281427, (Sheep) 493887
