Fabgennix

Presenilin 1 Polyclonal Antibody, Biotin

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产品信息

PSEN-101-BIOTIN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

产品规格

种属反应

Bovine, Cat, Human, Non-human primate, Pig

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 1-50 on Presenilin 1 (Alzheimer disease 3) protein.

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偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Alzheimer Disease 3; Minilin; presenilin 1 (Alzheimer disease 3); Presenilin-1; presenilin1; Protein S182; PS-1; S182 protein; Senilin 1

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基因别名: AD3; FAD; PS-1; PS1; PSEN1; PSNL1; S182

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UniProt ID: (Bovine) Q9XT97, (Human) P49768

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Entrez Gene ID: (Bovine) 282705, (Pig) 780411, (Human) 5663

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calcium channel activity PDZ domain binding aspartic endopeptidase activity, intramembrane cleaving endopeptidase activity aspartic-type endopeptidase activity protein binding beta-catenin binding cadherin binding aspartic protease

参与通路

autophagosome assembly negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity blood vessel development cell fate specification somitogenesis neuron migration positive regulation of receptor recycling heart looping positive regulation of L-glutamate transport hematopoietic progenitor cell differentiation astrocyte activation involved in immune response T cell activation involved in immune response protein glycosylation membrane protein ectodomain proteolysis mitochondrial transport cellular response to DNA damage stimulus response to oxidative stress negative regulation of epidermal growth factor-activated receptor activity Notch signaling pathway memory post-embryonic development regulation of neuron projection development protein transport choline transport synaptic vesicle targeting protein processing cerebral cortex cell migration Cajal-Retzius cell differentiation dorsal/ventral neural tube patterning embryonic limb morphogenesis positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum calcium ion homeostasis beta-amyloid formation intracellular signal transduction positive regulation of protein import into nucleus positive regulation of tumor necrosis factor biosynthetic process amyloid precursor protein metabolic process myeloid dendritic cell differentiation positive regulation of apoptotic process positive regulation of catalytic activity skin morphogenesis positive regulation of glycolytic process positive regulation of transcription, DNA-templated regulation of synaptic plasticity thymus development neuron development skeletal system morphogenesis brain morphogenesis epithelial cell proliferation negative regulation of axonogenesis synapse organization positive regulation of coagulation T cell receptor signaling pathway neuron apoptotic process negative regulation of ubiquitin-protein transferase activity regulation of synaptic transmission, glutamatergic regulation of resting membrane potential regulation of canonical Wnt signaling pathway positive regulation of dendritic spine development calcium ion transmembrane transport modulation of age-related behavioral decline cell-cell adhesion cellular response to beta-amyloid negative regulation of core promoter binding positive regulation of amyloid fibril formation neuron projection maintenance negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway neural retina development Notch receptor processing L-glutamate transport single organismal cell-cell adhesion regulation of phosphorylation amyloid precursor protein catabolic process negative regulation of apoptotic process regulation of protein binding positive regulation of MAP kinase activity negative regulation of neuron apoptotic process smooth endoplasmic reticulum calcium ion homeostasis canonical Wnt signaling pathway