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Prohibitin Antibody (PA5-85375) in ICC/IF
Prohibitin Polyclonal Antibody detects Prohibitin protein at mitochondria by immunofluorescent analysis. Sample: SKNSH cells were fixed in 2% paraformaldehyde/culture medium at 37°C for 30 min. Green: Prohibitin protein stained by Prohibitin Polyclonal Antibody (Product # PA5-85375) diluted at 1:1,000. Blue: Hoechst 33342 staining.
产品信息
PA5-85375
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human Prohibitin.
偶联物
形式
Liquid
浓度
0.91 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792517
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (94%), Xenopus laevis (89%), Dog (100%), Cat (100%), Chicken (96%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%).
Positive Control: IMR32, U87-MG, Neuro2A, GL261, C8D30, PC-12, Rat2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell receptor-associated protein 32; BAP 32; epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; prohibitin; Prohibitin 1
基因别名: Bap32; HEL-215; HEL-S-54e; PHB; PHB1
UniProt ID: (Human) P35232, (Mouse) P67778, (Rat) P67779
Entrez Gene ID: (Human) 5245, (Mouse) 18673, (Rat) 25344
RNA polymerase II transcription factor activity, sequence-specific DNA binding
complement component C3a binding
complement component C3b binding
protein binding
protein C-terminus binding
enzyme binding
proteinase activated receptor binding
histone deacetylase binding
transcription regulatory region DNA binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
regulation of transcription, DNA-templated
mitochondrion organization
signal transduction
negative regulation of cell proliferation
negative regulation of transcription by competitive promoter binding
histone deacetylation
negative regulation of cell growth
negative regulation of protein catabolic process
regulation of apoptotic process
positive regulation of G-protein coupled receptor protein signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of complement activation
protein stabilization
progesterone receptor signaling pathway
negative regulation of androgen receptor signaling pathway
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to interleukin-6
DNA biosynthetic process
negative regulation of glucocorticoid receptor signaling pathway
transcription from RNA polymerase II promoter
negative regulation of apoptotic process
ovarian follicle development
ovarian follicle atresia
organ regeneration
response to cytokine
response to immobilization stress
response to drug
response to peptide hormone
response to ethanol
