Invitrogen

Prolactin Receptor Monoclonal Antibody (B6.2)

Prolactin Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Prolactin Receptor Antibody (MA5-11955) in IHC (P)

Formalin-fixed, paraffin-embedded human breast cancer stained with Prolectin Receptor antibody using peroxidase-conjugate and AEC chromogen. Note cell membrane and cytoplasmic staining of tumor cells.

Prolactin Receptor Antibody in Western Blot, Immunohistochemistry (WB, IHC)

Prolactin Receptor Antibody in Immunohistochemistry (IHC)

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产品信息

MA5-11955

应用

建议稀释比

已发表文章

免疫印迹 (WB)

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1-2 µg/mL

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

B6.2

抗原

Semi-purified human prolactin receptor

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10989304

产品详细信息

MA5-11955 targets Prolactin Receptor in IHC (P) applications and shows reactivity with Human samples.

The MA5-11955 immunogen is semi-purified human prolactin receptor.

靶标信息

Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Pineal Diffuse Large B-Cell Lymphoma Concomitant With Pituitary Prolactinoma: Possible Correlation Between 2 Distinguished Pathologies: A Case Report.

Medicine

Kim YJ,Kim HK,Yang DH,Jung S,Noh MG,Lee JH,Lee KH,Moon KS

MA5-11955 was used in immunohistochemistry and western blot to analyze a case report involving pineal diffuse large B-cell lymphoma concomitant with pituitary prolactinoma and a possible correlation between two pathologies

Mon Feb 01 00:00:00 EST 2016

Pineal Diffuse Large B-Cell Lymphoma Concomitant With Pituitary Prolactinoma: Possible Correlation Between 2 Distinguished Pathologies: A Case Report.

Medicine

Kim YJ,Kim HK,Yang DH,Jung S,Noh MG,Lee JH,Lee KH,Moon KS

Mon Feb 01 00:00:00 EST 2016

Amplification of the prolactin receptor gene in mammary lobular neoplasia.

Breast cancer research and treatment

Tran-Thanh D,Arneson NC,Pintilie M,Deliallisi A,Warren KS,Bane A,Done SJ

MA5-11955 was used in immunohistochemistry to study amplification of the prolactin receptor gene in mammary neoplasia.

Fri Jul 01 00:00:00 EDT 2011

Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.

Breast cancer research : BCR

Howell SJ,Anderson E,Hunter T,Farnie G,Clarke RB

MA5-11955 was used in immunocytochemistry to study the role of prolactin receptor antagonism in doxorubicin and paclitaxel cytoxicity

Fri Apr 24 00:00:00 EDT 2009

Prolactin receptor expression in gynaecomastia and male breast carcinoma.

Histopathology

Ferreira M,Mesquita M,Quaresma M,André S

MA5-11955 was used in immunohistochemistry to study differential prolactin receptor expression in gynaecomastia and male breast carcinoma

Tue Jul 01 00:00:00 EDT 2008

Reversed Expression of the JAK/STAT Pathway Related Proteins Prolactin Receptor and STAT5a in Normal and Abnormal Breast Epithelial Cells.

Breast cancer : basic and clinical research

Bratthauer GL,Strauss BL,Barner R

MA5-11955 was used in immunohistochemistry to investigate PRLR and STAT5a expression in breast tissues

Thu Jul 14 00:00:00 EDT 2011

Expression of prolactin receptor and prolactin in normal and malignant thyroid: a tissue microarray study.

Endocrine pathology

Costa P,Catarino AL,Silva F,Sobrinho LG,Bugalho MJ

MA5-11955 was used in immunohistochemistry to study the expression of prolactin receptor and prolactin in normal and malignant thyroid using tissue microarrays