Invitrogen

Protein APC Monoclonal Antibody (FE9)

查看其他23个Protein APC抗体

产品信息

MA1-91039

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-1.5 µg/mL

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

FE9

抗原

synthetic peptide corresponding to the N-terminal 35 amino acid residues of APC.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein G

保存液

0.05M sodium phosphate, pH 7.5, with 0.2% gelatin

内含物

0.1% sodium azide

保存条件

4° C, do not freeze

运输条件

Wet ice

RRID

AB_1954862

产品详细信息

Reacts with all full length and truncated APC proteins.

MA1-91039 has been successfully used in Western blot applications, where a band of approximately 312 kDa is predicted to be detected. Suggested positive controls for this product are HCT116 cells for p300 and SW480 cells for truncated APC (p147).

靶标信息

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; Adenomatous polyposis coli protein; Deleted in polyposis 2.5; FPC; multiple intestinal neoplasia; Protein APC; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator

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基因别名: AI047805; APC; AU020952; AW124434; BTPS2; CC1; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46; RATAPC

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UniProt ID: (Human) P25054, (Rat) P70478

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Entrez Gene ID: (Human) 324, (Mouse) 11789, (Rat) 24205

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protein binding beta-catenin binding microtubule binding protein kinase regulator activity protein kinase binding protein complex binding gamma-catenin binding cadherin binding microtubule plus-end binding protease binding

参与通路

mitotic cytokinesis kidney development hair follicle development protein complex assembly cellular response to DNA damage stimulus negative regulation of microtubule depolymerization cell cycle arrest metaphase/anaphase transition of mitotic cell cycle mitotic spindle assembly checkpoint establishment or maintenance of cell polarity pattern specification process axonogenesis negative regulation of cell proliferation axis specification anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation Wnt signaling pathway cell migration stem cell population maintenance negative regulation of Wnt signaling pathway regulation of cell migration positive regulation of cell migration regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of pseudopodium assembly regulation of microtubule-based process T cell differentiation in thymus somatic stem cell population maintenance negative regulation of odontogenesis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of MAPK cascade skin development canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process regulation of cell differentiation positive regulation of cell differentiation regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cell adhesion muscle cell cellular homeostasis thymus development negative regulation of epithelial cell proliferation regulation of nitrogen compound metabolic process chromosome organization regulation of cell cycle positive regulation of cell division regulation of attachment of spindle microtubules to kinetochore retina development in camera-type eye canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development negative regulation of canonical Wnt signaling pathway regulation of glutamate metabolic process pancreas development response to drug response to alcohol cellular response to nerve growth factor stimulus cell fate specification cellular component disassembly involved in execution phase of apoptosis cell adhesion proteasome-mediated ubiquitin-dependent protein catabolic process bicellular tight junction assembly beta-catenin destruction complex assembly beta-catenin destruction complex disassembly