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QPRT Antibody (MA5-25199) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a QPRT monoclonal antibody (Product # MA5-25199).
产品信息
MA5-25199
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI4E6
抗原
Full length human recombinant protein of QPRT produced in HEK293T cell
偶联物
形式
Liquid
浓度
0.83 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2723541
靶标信息
QPRT gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis secretory sperm binding protein Li 90n; nicotinate-nucleotide pyrophosphorylase (carboxylating); Nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; Quinolinate phosphoribosyltransferase [decarboxylating]
基因别名: HEL-S-90n; QPRT; QPRTase
UniProt ID: (Human) Q15274
Entrez Gene ID: (Human) 23475
