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RAB3GAP1 Antibody (PA5-120651) in WB
Western blot analysis of RAB3GAP1 in extracts of various cell lines. Samples were incubated with RAB3GAP1 Polyclonal antibody (Product # PA5-120651) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3 min.
产品信息
PA5-120651
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 500-780 of human RAB3GAP1 (NP_001165906.1).
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914223
产品详细信息
Positive test controls include: HeLa, HepG2, Jurkat, Mouse lung, Mouse brain, Rat brain.
Immunogen sequence: GLASGPPDLR CCLLHQKLQM LNCCIERKKA RDEGKKTSAS DVTNIYPGDA GKAGDQLVPD NLKETDKEKG EVGKSWDSWS DSEEEFFECL SDTEELKGNG QESGKKGGPK EMANLRPEGR LYQHGKLTLL HNGEPLYIPV TQEPAPMTED LLEEQSEVLA KLGTSAEGAH LRARMQSACL LSDMESFKAA NPGCSLEDFV RWYSPRDYIE EEVIDEKGNV VLKGELSARM KIPSNMWVEA WETAKPIPAR RQRRLFDDTR EAEKVLHYLA IQKPADLARH L
靶标信息
RAB3GAP1, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Rab 3 GAP p130; Rab3 GAP p130; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic subunit; Rab3-GAP; Rab3-GAP p130
基因别名: 1700003B17Rik; 4732493F09Rik; AL117896; KIAA0066; P130; RAB3GAP; RAB3GAP1; RAB3GAP130; WARBM1
UniProt ID: (Human) Q15042, (Mouse) Q80UJ7
Entrez Gene ID: (Human) 22930, (Mouse) 226407
brain development
positive regulation of gene expression
hypothalamus development
lipid particle organization
camera-type eye development
regulation of GTPase activity
positive regulation of GTPase activity
regulation of short-term neuronal synaptic plasticity
excitatory postsynaptic potential
face morphogenesis
positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
establishment of protein localization to endoplasmic reticulum membrane
positive regulation of protein lipidation
regulation of calcium ion-dependent exocytosis of neurotransmitter
positive regulation of endoplasmic reticulum tubular network organization
positive regulation of autophagosome assembly
regulation of synaptic vesicle priming
synaptic vesicle transport
protein stabilization
