Proteintech

RAC2 Polyclonal Antibody

RAC2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RAC2 Antibody (10735-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 10735-1-AP ( RAC2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

RAC2 Antibody in Immunoprecipitation (IP)

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产品信息

10735-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看6篇已发表文章 6篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

RAC2 Fusion Protein Ag1202 (1-192 aa encoded by BC001485)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.23 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MQAIKCVVV GDGAVGKTCL LISYTTNAFP GEYIPTVFDN YSANVMVDSK PVNLGLWDTA GQEDYDRLRP LSYPQTDVFL ICFSLVSPAS YENVRAKWFP EVRHHCPSTP IILVGTKLDL RDDKDTIEKL KEKKLAPITY PQGLALAKEI DSVKYLECSA LTQRGLKTVF DEAIRAVLCP QPTRQQKRAC SLL (1-192 aa encoded by BC001485)

靶标信息

RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.

Journal of experimental & clinical cancer research : CR

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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

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生物信息学

蛋白别名: EN-7 protein; GX; p21-Rac2; Protein EN-7; RAS-related C3 botulinum substrate 2; Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Small G protein

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基因别名: AI323801; AI452260; EN-7; Gx; HSPC022; p21-Rac2; RAC2

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UniProt ID: (Human) P15153, (Mouse) Q05144

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Entrez Gene ID: (Human) 5880, (Rat) 366957, (Mouse) 19354

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功能

GTPase activity GTP binding protein kinase regulator activity nucleotide binding small GTPase

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