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Immunogen sequence: PCIPTLIGT PVKIGEGMLA DFVSQTSPMI PSIVVHCVNE IEQRGLTETG LYRISGCDRT VKELKEKFLR VKTVPLLSKV DDIHAICSLL KDFLRNLKEP LLTFRLNRAF MEAAEITDED NSIAAMYQAV GELPQANRDT LAFLMIHLQR VAQSPHTKMD VANLAKVFGP TIVAHAVPNP DPVTMLQDIK RQPKVVERLL SLPLEYWSQF MMVEQENIDP LHVIENSNAF STPQTPDIKV SLLGPVTTPE HQLLKTPSSS SLSQRVRSTL TKNTPRFGSK SKSATNLGRQ GNFFASPMLK (334-632 aa encoded by BC032754)
RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AKT; CYK4; ID; Male germ cell RacGap; MGC99656; MgcRacGAP; PKB-ALPHA; PRKBA; protein CYK4 homolg; Protein CYK4 homolog; RAC; Rac GTPase-activating protein 1; RAC-ALPHA; racgap1
基因别名: AI227039; AI327394; Band25; CYK4; gtl11; GTPase; HsCYK-4; ID-GAP; KIAA1478; MGCRACGAP; mKIAA1478; RACGAP1
UniProt ID: (Human) Q9H0H5, (Mouse) Q9WVM1
Entrez Gene ID: (Human) 29127, (Mouse) 26934
分子生物学功能:
GTPase-activating protein