Invitrogen

RACGAP1 Monoclonal Antibody (23A8)

产品信息

MA1-20580

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-2 µg/mL

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免疫组化（冰冻） (IHC (F))

10 µg/mL

免疫细胞化学 (ICC/IF)

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免疫沉淀 (IP)

4 µg

中和实验 (Neu)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

23A8

抗原

Recombinant, full length, human RAC protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

TBS with 30% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_560813

产品详细信息

Recommended positive controls: rat brain microsomal protein.

MA1-20580 detects a band of approximately 21 kDa.

靶标信息

RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions.

Nature communications

Li X,He L,Luo J,Zheng Y,Zhou Y,Li D,Zhang Y,Pan Z,Li Y,Tao L

MA1-20580 was used in Western Blotting to reveal the importance of TMPRSS2 and surface fucosylation in Hemorrhagic toxin actions and further provide insights into host recognition mechanisms for large clostridial toxins.

Tue Jul 26 00:00:00 EDT 2022

Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation.

The Journal of biological chemistry

Schael S,Nüchel J,Müller S,Petermann P,Kormann J,Pérez-Otaño I,Martínez SM,Paulsson M,Plomann M

MA1-20580 was used in immunocytochemistry and western blot to examine the involvement of PACSIN 1 in the BDNF-induced spine formation

Fri Mar 29 00:00:00 EDT 2013

Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6.

Molecular cancer research : MCR

Bhanot H,Young AM,Overmeyer JH,Maltese WA

MA1-20580 was used in blocking or activating experiment to investigate the role of Ras, Rac1 and Arf6 in methuosis

Fri Oct 01 00:00:00 EDT 2010

Nitric oxide and cyclic GMP regulate early events in agrin signaling in skeletal muscle cells.

Experimental cell research

Godfrey EW,Schwarte RC

MA1-20580 was used in western blot to study the involvement of nitric oxide and cyclic GMP in agrin signaling in skeletal muscle cells

Thu Jul 15 00:00:00 EDT 2010

生物信息学

蛋白别名: AKT; CYK4; ID; Male germ cell RacGap; MGC99656; MgcRacGAP; PKB-ALPHA; PRKBA; protein CYK4 homolg; Protein CYK4 homolog; RAC; Rac GTPase-activating protein 1; RAC-ALPHA; racgap1

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基因别名: AI227039; AI327394; Band25; CYK4; gtl11; GTPase; HsCYK-4; ID-GAP; KIAA1478; MGCRACGAP; mKIAA1478; RACGAP1

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UniProt ID: (Human) Q9H0H5, (Mouse) Q9WVM1

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Entrez Gene ID: (Human) 29127, (Mouse) 26934, (Rat) 315298

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