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Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients.
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蛋白别名: Retinoic acid-induced protein 1; Smith-Magenis syndrome chromosome region
基因别名: KIAA1820; RAI1; SMCR; SMS
UniProt ID: (Human) Q7Z5J4
Entrez Gene ID: (Human) 10743
分子生物学功能: zinc finger transcription factor