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RAMP1 (extracellular) Antibody (ARR-021-200UL) in ICC/IF
Expression of RAMP1 in rat PC12 cells - Cell surface detection of RAMP1 in intact living rat pheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-RAMP1 (extracellular) Antibody (#ARR-021), (1:50), (red). B. Live view of cells.
产品信息
ARR-021-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CRDPDYGTLIQE, corresponding to amino acid residues 27-38 of rat RAMP1, Extracellular, N-terminus
偶联物
Unconjugated
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC38240; receptor (calcitonin) activity modifying protein 1; Receptor activity-modifying protein 1
基因别名: 9130218E19Rik; Ramp1
UniProt ID: (Rat) Q9JJ74, (Mouse) Q9WTJ5
Entrez Gene ID: (Rat) 58965, (Mouse) 51801
angiogenesis
calcium ion transport
intracellular protein transport
signal transduction
G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
positive regulation of protein glycosylation
protein localization to plasma membrane
transport
