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产品信息
25297-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RBM25 Fusion Protein Ag18244 (609-843 aa encoded by BC113389)
偶联物
Unconjugated
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: QKPCLKPTL RPISSAPSVS SASGNATPNT PGDESPCGII IPHENSPDQQ QPEEHRPKIG LSLKLGASNS PGQPNSVKRK KLPVDSVFNK FEDEDSDDVP RKRKLVPLDY GEDDKNATKG TVNTEEKRKH IKSLIEKIPT AKPELFAYPL DWSIVDSILM ERRIRPWINK KIIEYIGEEE ATLVDFVCSK VMAHSSPQSI LDDVAMVLDE EAEVFIVKMW RLLIYETEAK KIGLVK (609-843 aa encoded by BC113389)
靶标信息
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Arg/Glu/Asp-rich protein of 120 kDa; Arg/Glu/Asp-rich protein, 120 kDa; functional spliceosome-associated protein 94; Protein S164; RED120; rna-binding; RNA-binding motif protein 25; RNA-binding protein 25; RNA-binding region (RNP1, RRM) containing 7; RNA-binding region-containing protein 7; U1 small nuclear ribonucleoprotein 1SNRP homolog
基因别名: 2600011C06Rik; 2610015J01Rik; A130095G20Rik; AI159652; AL023075; AU043498; fSAP94; NET52; RBM25; RED120; RNPC7; S164; Snu71
UniProt ID: (Human) P49756, (Mouse) B2RY56
Entrez Gene ID: (Human) 58517, (Mouse) 67039
