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This antibody is a rabbit polyclonal antibody raised against full length RCC1 of human origin.
Immunogen sequence: MSPKRIAKR RSPPADAIPK SKKVKVSHRS HSTEPGLVLT LGQGDVGQLG LGENVMERKK PALVSIPEDV VQAEAGGMHT VCLSKSGQVY SFGCNDEGAL GRDTSVEGSE MVPGKVELQE KVVQVSAGDS HTAALTDDGR VFLWGSFRDN NGVIGLLEPM KKSMVPVQVQ LDVPVVKVAS GNDHLVMLTA DGDLYTLGCG EQGQLGRVPE LFANRGGRQG LERLLVPKCV MLKSRGSRGH VRFQDAFCGA YFTFAISHEG HVYGFGLSNY HQLGTPGTES CFIPQNLTSF KNSTKSWVGF SGGQHHTVCM DSEGKAYSLG RAEYGRLGLG EGAEEKSIPT LISRLPAVSS VACGASVGYA VTKDGRVFAW GMGTNYQLGT GQDEDAWSPV EMMGKQLENR VVLSVSSGGQ HTVLLVKDKE QS (1-421 aa encoded by BC010067)
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cell cycle regulatory protein; Chromosome condensation protein 1; guanine nucleotide-releasing protein; Regulator of chromosome condensation; SNHG3-RCC1 readthrough
基因别名: 4931417M11Rik; AI326872; CHC1; RCC1; RCC1-I; SNHG3-RCC1
UniProt ID: (Human) P18754, (Mouse) Q8VE37
Entrez Gene ID: (Human) 1104, (Mouse) 100088, (Rat) 682908