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Antibody detects endogenous levels of total RFC2.
This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: A1 40 kDa subunit; Activator 1 40 kDa subunit; Activator 1 subunit 2; Activator 1 subunit C2; MGC3665; replication factor C (activator 1) 2, 40kDa; Replication factor C 40 kDa subunit; Replication factor C subunit 2; replication factor C, 40 kDa; RF-C 40 kDa subunit; RFC40
基因别名: 2610008M13Rik; 40kDa; AI326953; Recc2; RFC2; RFC40
UniProt ID: (Human) P35250, (Mouse) Q9WUK4, (Rat) Q641W4
Entrez Gene ID: (Human) 5982, (Mouse) 19718, (Rat) 116468
分子生物学功能:
DNA-directed DNA polymerase