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产品信息
PA5-54081
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646505
产品详细信息
Immunogen sequence: PHFPCLQKLL DYLTRMMPGS DPERRAQNLL EQFQKQEVET DNGLPNTISF SLEEEEELEG GESAEFTCFS EDLVAEQLTY MDAQLFKKVV PHHCLGCIWS RRD
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 87%.
靶标信息
Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL1 (ral guanine nucleotide dissociation stimulator-like 1), also known as RGL or RalGDS-like 1, is a 768 amino acid protein that is a putative GEF. Strongly expressed in brain, heart, spleen, kidney and testis, RGL1 is a downstream effector protein that is involved in Ras and Ral signaling pathways. RGL1 contains an N-terminal Ras-GEF domain and a C-terminal Ras-interacting domain that interacts with the GTP-bound form of Ras through its effector loop. Due to its similarity to Ral GDS, RGL1 may be implicated in carcinogenesis. Two isoforms exist due to alternative splicing events.
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生物信息学
蛋白别名: Ral guanine nucleotide dissociation stimulator-like 1; RalGDS-like 1
基因别名: KIAA0959; RGL; RGL1
UniProt ID: (Human) Q9NZL6
Entrez Gene ID: (Human) 23179
