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Antibody detects endogenous levels of total RIC8A.
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: heterotrimeric G protein guanine nucleotide exchange factor Ric-8A; MGC104517; MGC131931; MGC148073; MGC148074; Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog; resistance to inhibitors of cholinesterase 8 homolog A; resistance to inhibitors of cholinesterase 8A; RIC8 protein; synembryn; Synembryn-A
基因别名: AI114950; RIC-8; Ric-8A; RIC8; RIC8A
UniProt ID: (Human) Q96EZ1, (Mouse) Q3TIR3
Entrez Gene ID: (Human) 60626, (Mouse) 101489, (Rat) 293614